{"doi":"10.1016/j.semcancer.2025.01.008","title":"Drivers of centrosome abnormalities: Senescence progression and tumor immune escape","abstract":null,"journal":"Seminars in Cancer Biology","year":2025,"id":677389,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":352541,"name":"Hua Jin","orcid":"0000-0001-9829-0306","position":1,"is_corresponding":false},{"id":1769934,"name":"Xintong Ji","orcid":null,"position":2,"is_corresponding":false},{"id":90190,"name":"Xi Zheng","orcid":null,"position":3,"is_corresponding":false},{"id":692930,"name":"Cheng-Xiong Xu","orcid":"0000-0001-5714-8207","position":4,"is_corresponding":false},{"id":1769935,"name":"Peng-Jun Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":883227,"name":"Tao Jiang","orcid":"0000-0002-8529-4487","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Drivers of centrosome abnormalities: Senescence progression and tumor immune escape","abstract":"Centrosome abnormalities are a distinguishing feature of cancer and play a role in the aging process. Cancer cells may evade the immune system by activating immune checkpoints, altering their surrounding microenvironment, abnormalities in antigen presentation and recognition, and metabolic reprogramming to inhibit T-cell activity, allowing cancer cells to survive and spread within the host. When the centrosomes are abnormally shaped or numbered, mitotic errors can occur, cellular senescence occurs, cell death occurs, genomic instability occurs, and aneuploidy forms, resulting in diseases such as cancer. The present study is exploring the strategy of research progress in which centrosome abnormalities contribute to the aging process in various different ways as well as fuel immune escape from cancer cells, providing a new direction for cancer immunotherapy.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39929410","pmcid":null,"openalex_id":"https://openalex.org/W4407264178","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Chongqing Municipality","grant_id":"CSTB2022NSCQ-MSX0362","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2022CDJYGRH-009","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2020YFC2004604","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2020YFC2002700","title":null},{"funder_name":"Chongqing Municipal Science and Technology Bureau","grant_id":"CSTB2022BSXM-JCX0080","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81972010","title":null}],"total_grants":6,"fwci":4.6713,"citation_percentile":0.94709388,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1044579X25000173?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1044579X25000173?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.semcancer.2025.01.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39929410","host_type":"repository"}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Epigenetics and DNA Methylation","Ocular Oncology and Treatments"],"mesh_terms":["Animals","Humans","Neoplasms","Cellular Senescence","Centrosome","Disease Progression","Tumor Escape","Tumor Microenvironment"],"keywords":["Centrosome","Senescence","Immune system","Biology","Cellular senescence","Immune escape","Tumor progression","Immunosenescence","Immunology","Cell biology","Genetics","Cancer","Gene","Phenotype","Cell cycle","Cell division","Chromosomal Instability","Immune Evasion","Centrosome Abnormalities"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T04:04:09.633167Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}