{"doi":"10.1016/j.scr.2023.103116","title":"Human induced pluripotent stem cell (iPSC) line (HEBHMUi014-A) derived from a patient with Alzheimer's disease","abstract":null,"journal":"Stem Cell Research","year":2023,"id":608271,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1394880,"name":"Mei Yu","orcid":"0000-0003-0306-6817","position":1,"is_corresponding":false},{"id":1562125,"name":"Ruiyun Guo","orcid":null,"position":2,"is_corresponding":false},{"id":889340,"name":"Yunfei Zhang","orcid":"0000-0002-8123-7805","position":3,"is_corresponding":false},{"id":332296,"name":"Xiaohan Zhang","orcid":"0000-0003-1522-4042","position":4,"is_corresponding":false},{"id":640110,"name":"Jingyi Sun","orcid":"0009-0004-5000-1092","position":5,"is_corresponding":false},{"id":500806,"name":"Jing Zhang","orcid":"0000-0002-4823-4629","position":6,"is_corresponding":false},{"id":393466,"name":"Xia Wang","orcid":"0000-0001-6650-5229","position":7,"is_corresponding":false},{"id":1220929,"name":"Jun Ma","orcid":"0000-0001-8375-4366","position":8,"is_corresponding":false},{"id":1562124,"name":"Mingjing Zhang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human induced pluripotent stem cell (iPSC) line (HEBHMUi014-A) derived from a patient with Alzheimer's disease","abstract":"The ε4 allele of the lipoprotein E gene (APOE4) is the strongest genetic risk factor associated with sporadic Alzheimer's disease (sAD). While the neuronal cell type-specific function of APOE4 in connection with AD pathology remains understudied. Therefore, we generated an induced pluripotent stem cells (iPSCs) line from a 77-year-old female donor with ApoE4 genetic background. We reprogrammed peripheral blood mononuclear cells (PBMCs) with non-integrative Sendai viral vectors containing reprogramming factors. Established iPSCs showed the capability of pluripotency, three-germ differentiation in vitro with normal karyotype. Hence, the generated iPSC could be a powerful tool to conduct further studies of AD mechanisms.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37178573","pmcid":null,"openalex_id":"https://openalex.org/W4376598262","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81801278","title":null},{"funder_name":"Natural Science Foundation of Hebei Province","grant_id":"H2019206637","title":null},{"funder_name":"Natural Science Foundation of Hebei Province","grant_id":"H2020206557","title":null},{"funder_name":"China Scholarship Council","grant_id":"201608130015","title":null}],"total_grants":4,"fwci":0.0,"citation_percentile":0.03736342,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.scr.2023.103116","host_type":"journal"},{"url":"https://doi.org/10.1016/j.scr.2023.103116","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1873506123001022?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1873506123001022?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37178573","host_type":"repository"},{"url":"https://doaj.org/article/96345dc54d904fd1bd026a3aa4e519d1","host_type":"repository"}],"fields_of_study":["Pluripotent Stem Cells Research","CRISPR and Genetic Engineering","Nuclear Receptors and Signaling","Female","Humans","Aged","Induced Pluripotent Stem Cells","Cellular Reprogramming","Alzheimer Disease","Apolipoprotein E4","Leukocytes, Mononuclear","Cell Line","Karyotype","Cell Differentiation"],"mesh_terms":["Aged","Alzheimer Disease","Cell Differentiation","Cell Line","Female","Humans","Leukocytes, Mononuclear","Apolipoprotein E4","Induced Pluripotent Stem Cells","Karyotype","Cellular Reprogramming"],"keywords":["Induced pluripotent stem cell","Reprogramming","Germ layer","Biology","Peripheral blood mononuclear cell","Karyotype","Sendai virus","Disease","Stem cell","Genetics","Cell biology","Cell","Embryonic stem cell","Gene","In vitro","Pathology","Chromosome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"ebisc"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:57:04.871930Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}