{"doi":"10.1016/j.scr.2020.102073","title":"Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2","abstract":null,"journal":"Stem Cell Research","year":2020,"id":682882,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1783924,"name":"Takefumi Sone","orcid":null,"position":1,"is_corresponding":false},{"id":1783925,"name":"Hideki Ukai","orcid":null,"position":2,"is_corresponding":false},{"id":1783927,"name":"Tomoko Hisamatsu","orcid":null,"position":3,"is_corresponding":false},{"id":1783928,"name":"Tokiko Kitagawa","orcid":null,"position":4,"is_corresponding":false},{"id":1714992,"name":"Mitsuru Ishikawa","orcid":null,"position":5,"is_corresponding":false},{"id":1783929,"name":"Makiko Nagai","orcid":null,"position":6,"is_corresponding":false},{"id":366637,"name":"Hiroki R. Ueda","orcid":"0000-0001-8342-9176","position":7,"is_corresponding":false},{"id":1783930,"name":"Fumiya Obata","orcid":null,"position":8,"is_corresponding":false},{"id":269746,"name":"Hideyuki Okano","orcid":"0000-0001-7482-5935","position":9,"is_corresponding":false},{"id":1783923,"name":"Etsuro Ohta","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2","abstract":"Leucine-rich repeat kinase 2 (LRRK2) is the causal gene of the autosomal dominant hereditary form of Parkinson's disease (PD), PARK8. We have previously reported that induced pluripotent stem cells (iPSCs) from a PARK8 patient with I2020T LRRK2 mutation replicated to some extent the pathologic phenotype evident in the brain of PD patients. In the present study, we generated gene-corrected iPSCs line, KEIUi001-A, using TALEN-mediated genome editing. KEIUi001-A retained a normal karyotype and pluripotency, i.e. the capacity to differentiate into cell types of the three germ layers. This iPSCs will be valuable for clarifying various aspects of LRRK2-related pathology.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33181472","pmcid":null,"openalex_id":"https://openalex.org/W3097561595","authors":[],"funders":[{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"20bm0804003h0104","title":null},{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"20bm0804023h0001","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"16bm0609003h0005","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"16ek0109013h0003","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"16ek0109158h0002","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"17bm0804003h0001","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"18bm0804003h0002","title":null},{"funder_name":"California Institute for Regenerative Medicine","grant_id":"19bm0804003h0003","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"17H05704","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"20K06914","title":null},{"funder_name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","grant_id":"","title":null}],"total_grants":11,"fwci":0.2524,"citation_percentile":0.59448928,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":1},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S1873506120303743/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S1873506120303743/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1873506120303743?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1873506120303743?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.scr.2020.102073","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33181472","host_type":"repository"},{"url":"https://doaj.org/article/e73f21c0818b474ab9a899da62495144","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","CRISPR and Genetic Engineering","Autism Spectrum Disorder Research"],"mesh_terms":["Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","Humans","Mutation","Parkinson Disease","Phenotype","Induced Pluripotent Stem Cells"],"keywords":["LRRK2","Induced pluripotent stem cell","Biology","Germ layer","Mutation","Phenotype","Gene","Genetics","Disease","Karyotype","Parkinson's disease","Genome editing","Cancer research","Genome","Pathology","Chromosome","Embryonic stem cell","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"ebisc"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T21:36:51.860827Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}