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However, our current views of proteomes are conservative and biased against small proteins. Besides serendipitous discoveries of small proteins, it has been largely assumed that eukaryotic mature mRNAs contain a single ORF and that non-coding RNAs are not translated because their ORFs are too short to play a functional role. A flurry of recent studies brought to light an unexplored proteome that is mainly translated from short ORFs in non-coding regions and from alternative ORFs (AltORFs) in reference genes. The detection of these small proteins and the elucidation of their functions remain challenging and open a new dimension of eukaryotic proteomes, including the birth of novel genes and proteins.","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25795211","pmcid":null,"openalex_id":"https://openalex.org/W2092207442","authors":[],"funders":[{"funder_name":"CIHR","grant_id":"324265","title":null},{"funder_name":"CIHR","grant_id":"299432","title":null},{"funder_name":"CIHR","grant_id":"MOP-137056","title":null},{"funder_name":"CIHR","grant_id":"MOP-136962","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"},{"funder_name":"NSERC Discovery","grant_id":"","title":null},{"funder_name":"FRQNT Team","grant_id":"","title":null}],"total_grants":7,"fwci":3.72,"citation_percentile":0.93990977,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":9},{"year":2017,"count":7},{"year":2018,"count":8},{"year":2019,"count":6},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2024,"count":10},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0959440X15000263?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0959440X15000263?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.sbi.2015.02.017","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25795211","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.sbi.2015.02.017","host_type":""}],"fields_of_study":["RNA and protein synthesis mechanisms","RNA modifications and cancer","RNA Research and Splicing","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Humans","RNA, Messenger","Protein Biosynthesis","Open Reading Frames","Proteome"],"keywords":["ORFS","Proteome","Biology","Human proteome project","Open reading frame","Computational biology","Gene","Genetics","Translation (biology)","Proteomics","Messenger RNA","Peptide sequence","Open Reading Frames","Protein Biosynthesis","Animals","Humans","RNA, Messenger"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T13:34:19.607823Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}