{"doi":"10.1016/j.sbi.2011.07.004","title":"Cryo-electron tomography: gaining insight into cellular processes by structural approaches","abstract":null,"journal":"Current Opinion in Structural Biology","year":2011,"id":686074,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792447,"name":"Tal Maimon","orcid":null,"position":1,"is_corresponding":false},{"id":1792448,"name":"Einat Grossman","orcid":null,"position":2,"is_corresponding":false},{"id":1792449,"name":"Idit Dahan","orcid":null,"position":3,"is_corresponding":false},{"id":201658,"name":"Ohad Medalia","orcid":null,"position":4,"is_corresponding":false},{"id":1792445,"name":"Tal Yahav","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cryo-electron tomography: gaining insight into cellular processes by structural approaches","abstract":"Visualization of cellular processes at a resolution of the individual protein should involve integrative and complementary approaches that can eventually draw realistic functional and cellular landscapes. Electron tomography of vitrified but otherwise unaltered cells emerges as a central method for three-dimensional reconstruction of cellular architecture at a resolution of 2-6 nm. While a combination of correlative light-based microscopy with cryo-electron tomography (cryo-ET) provides medium-resolution insight into pivotal cellular processes, fitting high-resolution structural approaches, for example, X-ray crystallography, into reconstructed macromolecular assemblies provides unprecedented information on native protein assemblies. Thus, cryo-ET bridges the resolution gap between cellular and structural biology. In this article, we focus on the study of eukaryotic cells and macromolecular complexes in a close-to-life-state. 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