{"doi":"10.1016/j.rpth.2023.100282","title":"Podoplanin and CLEC-2 levels in patients with COVID-19","abstract":null,"journal":"Research and Practice in Thrombosis and Haemostasis","year":2023,"id":634530,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1645727,"name":"Franciele Lima","orcid":null,"position":1,"is_corresponding":false},{"id":848164,"name":"Davi Sidarta-Oliveira","orcid":"0000-0003-2530-6666","position":2,"is_corresponding":false},{"id":1645729,"name":"Carla Roberta Peachazepi Moraes","orcid":null,"position":3,"is_corresponding":false},{"id":1645730,"name":"Joyce M. Annichino-Bizzacchi","orcid":null,"position":4,"is_corresponding":false},{"id":1645731,"name":"Bruna Bombassaro","orcid":null,"position":5,"is_corresponding":false},{"id":1645732,"name":"André C. Palma","orcid":null,"position":6,"is_corresponding":false},{"id":295839,"name":"Fábio Trindade Maranhão Costa","orcid":"0000-0001-9969-7300","position":7,"is_corresponding":false},{"id":1645734,"name":"Maria Luiza Moretti","orcid":null,"position":8,"is_corresponding":false},{"id":1645735,"name":"Eli Mansour","orcid":null,"position":9,"is_corresponding":false},{"id":1645737,"name":"Lício Augusto Velloso","orcid":null,"position":10,"is_corresponding":false},{"id":1235830,"name":"Fernanda Andrade Orsi","orcid":"0000-0002-7908-9073","position":11,"is_corresponding":false},{"id":1645739,"name":"Erich Vinicius De Paula","orcid":null,"position":12,"is_corresponding":false},{"id":1645725,"name":"Ivanio Teixeira Borba-Junior","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Podoplanin and CLEC-2 levels in patients with COVID-19","abstract":"<h4>Introduction</h4>Podoplanin (<i>PDPN</i> gene) and CLEC-2 are involved in inflammatory hemostasis and have also been related with the pathogenesis of thrombosis. Emerging evidence also suggest that podoplanin can exert protective effects in sepsis and in acute lung injury. In lungs, podoplanin is co-expressed with ACE2, which is the main entry receptor for SARS-CoV-2.<h4>Aim</h4>To explore the role of podoplanin and CLEC-2 in COVID-19.<h4>Methods</h4>Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex-matched healthy individuals. Podoplanin expression in lungs from patients who died of COVID-19 was obtained from two independent public databases of single-cell RNAseq from which data from control lungs were also available.<h4>Results</h4>Circulating podoplanin levels were lower in COVID-19, while no difference was observed in CLEC-2 levels. Podoplanin levels were significantly inversely correlated with markers of coagulation, fibrinolysis and innate immunity. scRNAseq data confirmed that <i>PDPN</i> is co-expressed with <i>ACE2</i> in pneumocytes, and showed that <i>PDPN</i> expression is lower in this cell compartment in lungs from patients with COVID-19.<h4>Conclusion</h4>Circulating levels of podoplanin are lower in COVID-19, and the magnitude of this reduction is correlated with hemostasis activation. We also demonstrate the downregulation of <i>PDPN</i> at the transcription level in pneumocytes. Together, our exploratory study questions whether an acquired podoplanin deficiency could be involved in the pathogenesis of acute lung injury in COVID-19, and warrant additional studies to confirm and refine these findings.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37361399","pmcid":"PMC10284445","openalex_id":null,"authors":[],"funders":[{"funder_name":"Fundação de Amparo à Pesquisa do Estado de São Paulo","grant_id":"2016/14172-6","title":null},{"funder_name":"Fundação de Amparo à Pesquisa do Estado de São Paulo","grant_id":"2020/05369-6","title":null},{"funder_name":"Fundação de Amparo à Pesquisa do Estado de São Paulo","grant_id":"2020/05985-9","title":null},{"funder_name":"FAEPEX","grant_id":"2404/2020","title":null},{"funder_name":"FAEPEX","grant_id":"","title":null},{"funder_name":"CAPES","grant_id":"","title":null},{"funder_name":"FAPESP","grant_id":"","title":null}],"total_grants":7,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.rpthjournal.org/article/S2475037923001826/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2475037923001826?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2475037923001826?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10284445/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10284445","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10284445?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Acute Lung Injury","Podoplanin","Clec-2","Scrnaseq","Covid-19"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:47:56.015518Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}