{"doi":"10.1016/j.rpth.2022.100016","title":"D-dimer and the risk of hypertension: The REasons for Geographic And Racial Differences in Stroke Cohort Study","abstract":"Background: Reasons for increased risk of hypertension in Black compared with White people are only partly understood. D-dimer, a thrombo-inflammatory marker higher in Black individuals, is also higher in people with hypertension. However, the impact of D-dimer on racial disparities in risk of incident hypertension has not been studied. Objectives: To assess whether D-dimer is associated with the risk of incident hypertension, whether the association between D-dimer and the risk of incident hypertension differs by race, and whether the biology reflected by D-dimer explains racial disparities in the risk of incident hypertension. Methods: This study included 1867 participants in the REasons for Geographic And Racial Differences in Stroke cohort study without baseline hypertension and with a second visit 9.4 years after baseline. Risk ratios of incident hypertension by baseline D-dimer level were estimated, a D-dimer-by-race interaction was tested, and the mediating effect of D-dimer (which represents underlying biological processes) on the association of race and hypertension risk was assessed. Results: The risk of incident hypertension was 47% higher in persons in the top quartile than in those in the bottom quartile of D-dimer (risk ratio [RR]: 1.47; 95% CI: 1.23-1.76). The association was partly attenuated after adjusting for sociodemographic and adiposity-related risk factors (RR: 1.22; 95% CI: 1.02-1.47). The association of D-dimer and hypertension did not differ by race, and D-dimer did not attenuate the racial difference in the risk of incident hypertension. Conclusion: D-dimer concentration reflects pathophysiology related to the development of hypertension. Specific mechanisms require further study and may involve adiposity.","journal":"Research and Practice in Thrombosis and Haemostasis","year":2023,"id":369392,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399554,"name":"Boyi Guo","orcid":"0000-0003-2950-2349","position":1,"is_corresponding":false},{"id":51225,"name":"D. Leann Long","orcid":"0000-0001-8614-7190","position":2,"is_corresponding":false},{"id":74972,"name":"Suzanne E. Judd","orcid":"0000-0001-7594-6587","position":3,"is_corresponding":false},{"id":399553,"name":"Timothy B. Plante","orcid":"0000-0001-9992-9597","position":4,"is_corresponding":false},{"id":276671,"name":"Leslie A. McClure","orcid":null,"position":5,"is_corresponding":false},{"id":249625,"name":"Alisa S. Wolberg","orcid":"0000-0002-2845-2303","position":6,"is_corresponding":false},{"id":374898,"name":"Neil A. Zakai","orcid":"0000-0001-8824-4410","position":7,"is_corresponding":false},{"id":103407,"name":"George Howard","orcid":"0000-0002-3068-5720","position":8,"is_corresponding":false},{"id":51219,"name":"Mary Cushman","orcid":"0000-0002-7871-6143","position":9,"is_corresponding":false},{"id":752317,"name":"Debora Kamin Mukaz","orcid":"0000-0001-5573-2573","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:15:28.704894Z","pmid":"36760775","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}