{"doi":"10.1016/j.reprotox.2015.02.002","title":"Medications as a source of paraben exposure","abstract":null,"journal":"Reproductive Toxicology","year":2015,"id":632962,"datarank":0.6716005221717312,"base_score":4.477336814478207,"endowment":4.477336814478207,"self_citation_contribution":0.6716005221717312,"citation_network_contribution":0.0,"self_endowment_contribution":0.6716005221717312,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":87,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1044698,"name":"Katherine E. Kelley","orcid":null,"position":1,"is_corresponding":false},{"id":368526,"name":"Paige L. Williams","orcid":"0000-0002-7160-574X","position":2,"is_corresponding":false},{"id":364473,"name":"Michelle A. Williams","orcid":"0000-0001-5807-5281","position":3,"is_corresponding":false},{"id":1640901,"name":"Sonia Hernández-Díaz","orcid":null,"position":4,"is_corresponding":false},{"id":300998,"name":"Stacey A. Missmer","orcid":"0000-0003-3147-6768","position":5,"is_corresponding":false},{"id":307047,"name":"Russ Hauser","orcid":"0000-0002-1899-3982","position":6,"is_corresponding":false},{"id":329830,"name":"Laura E. Dodge","orcid":"0000-0002-4024-2034","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Medications as a source of paraben exposure","abstract":"<h4>Background</h4>Parabens are used as antimicrobial excipients in some pharmaceuticals. Parabens may adversely affect reproduction.<h4>Objectives</h4>Determine whether paraben-containing medication contributes to high urinary paraben concentrations.<h4>Methods</h4>Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples \"exposed\" and \"unexposed\" to paraben-containing medication.<h4>Results</h4>Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7h was associated with 8.7-fold and 7.5-fold increases in mean methyl (P=0.11) and propyl (P=0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P=0.76) and 2.6-fold (P=0.34), respectively, after removal of one influential individual.<h4>Conclusion</h4>Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.","is_dataset_classified":null,"base_score":4.477336814478207,"endowment":4.477336814478207,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25728410","pmcid":"PMC4426043","openalex_id":"https://openalex.org/W2036625778","authors":[],"funders":[{"funder_name":"NIEHS","grant_id":"ES009718","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD059861","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"T32 ES007069","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES009718","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"T32ES 07069","title":null}],"total_grants":5,"fwci":3.8454,"citation_percentile":0.93123347,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":5},{"year":2017,"count":5},{"year":2018,"count":9},{"year":2019,"count":6},{"year":2020,"count":17},{"year":2021,"count":11},{"year":2022,"count":15},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4426043","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4426043","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0890623815000143?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0890623815000143?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.reprotox.2015.02.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25728410","host_type":"repository"}],"fields_of_study":["Effects and risks of endocrine disrupting chemicals","Folate and B Vitamins Research","Pharmacological Effects and Toxicity Studies","Adolescent","Adult","Anti-Infective Agents","Environmental Exposure","Female","Fertility","Fertilization in Vitro","Humans","Insemination, Artificial, Homologous","Male","Middle Aged","Parabens","Pregnancy","Preservatives, Pharmaceutical","Prospective Studies","Urine","Young Adult"],"mesh_terms":["Adolescent","Adult","Anti-Infective Agents","Environmental Exposure","Female","Fertility","Fertilization in Vitro","Humans","Insemination, Artificial, Homologous","Male","Middle Aged","Parabens","Pregnancy","Preservatives, Pharmaceutical","Prospective Studies","Urine","Young Adult"],"keywords":["Paraben","Urine","Urinary system","Antimicrobial","Medicine","Chemistry","Toxicology","Physiology","Pharmacology","Preservative","Internal medicine","Food science","Biology","Endocrine system","Pharmaceuticals","Parabens","Assisted Reproductive Technologies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:39:50.460732Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}