{"doi":"10.1016/j.redox.2022.102465","title":"Redox imbalance in COVID-19 pathophysiology","abstract":"BACKGROUND: The pathophysiologic significance of redox imbalance is unquestionable as numerous reports and topic reviews indicate alterations in redox parameters during corona virus disease 2019 (COVID-19). However, a more comprehensive understanding of redox-related parameters in the context of COVID-19-mediated inflammation and pathophysiology is required. METHODS: COVID-19 subjects (n = 64) and control subjects (n = 19) were enrolled, and blood was drawn within 72 h of diagnosis. Serum multiplex assays and peripheral blood mRNA sequencing was performed. Oxidant/free radical (electron paramagnetic resonance (EPR) spectroscopy, nitrite-nitrate assay) and antioxidant (ferrous reducing ability of serum assay and high-performance liquid chromatography) were performed. Multivariate analyses were performed to evaluate potential of indicated parameters to predict clinical outcome. RESULTS: Significantly greater levels of multiple inflammatory and vascular markers were quantified in the subjects admitted to the ICU compared to non-ICU subjects. Gene set enrichment analyses indicated significant enhancement of oxidant related pathways and biochemical assays confirmed a significant increase in free radical production and uric acid reduction in COVID-19 subjects. Multivariate analyses confirmed a positive association between serum levels of VCAM-1, ICAM-1 and a negative association between the abundance of one electron oxidants (detected by ascorbate radical formation) and mortality in COVID subjects while IL-17c and TSLP levels predicted need for intensive care in COVID-19 subjects. CONCLUSION: and/or circulating transition metals such as Fe or Cu) contributing to this imbalance to avoid the repetition of failures using non-specific antioxidant supplementation.","journal":"Redox Biology","year":2022,"id":251378,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9058,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":894280,"name":"Vishal Deepak","orcid":"0000-0001-7601-8985","position":1,"is_corresponding":false},{"id":894281,"name":"Sarah Hadique","orcid":"0000-0003-3140-4529","position":2,"is_corresponding":false},{"id":699931,"name":"Drake Aesoph","orcid":null,"position":3,"is_corresponding":false},{"id":313064,"name":"Murugesan Velayutham","orcid":null,"position":4,"is_corresponding":false},{"id":320740,"name":"Qing Ye","orcid":"0000-0002-6756-0630","position":5,"is_corresponding":false},{"id":749852,"name":"Md Habibul Hasan Mazumder","orcid":"0000-0002-7807-8372","position":6,"is_corresponding":false},{"id":471316,"name":"Sara E. Lewis","orcid":"0000-0001-8119-7076","position":7,"is_corresponding":false},{"id":368819,"name":"Vamsi Kodali","orcid":"0000-0001-6177-0568","position":8,"is_corresponding":false},{"id":894693,"name":"A. Roohollahi","orcid":null,"position":9,"is_corresponding":false},{"id":277458,"name":"Nancy Lan Guo","orcid":"0000-0002-8050-6268","position":10,"is_corresponding":false},{"id":331852,"name":"Gangqing Hu","orcid":"0000-0001-5453-6888","position":11,"is_corresponding":false},{"id":430911,"name":"Valery V. Khramtsov","orcid":"0000-0001-6187-5546","position":12,"is_corresponding":false},{"id":247939,"name":"Richard J. Johnson","orcid":"0000-0003-3312-8193","position":13,"is_corresponding":false},{"id":320495,"name":"Sijin Wen","orcid":"0000-0002-6955-2917","position":14,"is_corresponding":false},{"id":247931,"name":"Eric E. Kelley","orcid":"0000-0002-0393-1498","position":15,"is_corresponding":false},{"id":292268,"name":"Salik Hussain","orcid":"0000-0003-0339-6226","position":16,"is_corresponding":false},{"id":667508,"name":"Nairrita Majumder","orcid":"0000-0002-7297-7019","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":null,"created_at":"2026-07-19T00:24:37.429628Z","pmid":"36116160","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}