{"doi":"10.1016/j.redox.2022.102304","title":"Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy","abstract":null,"journal":"Redox Biology","year":2022,"id":599970,"datarank":0.7814229229262133,"base_score":5.209486152841421,"endowment":5.209486152841421,"self_citation_contribution":0.7814229229262133,"citation_network_contribution":0.0,"self_endowment_contribution":0.7814229229262133,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":182,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":667866,"name":"Sarah Krantz","orcid":"0000-0001-8451-2238","position":1,"is_corresponding":false},{"id":473441,"name":"Xiang Qin","orcid":"0000-0003-1595-9700","position":2,"is_corresponding":false},{"id":776866,"name":"Shun Li","orcid":"0000-0002-8580-3843","position":3,"is_corresponding":false},{"id":1112405,"name":"Hirushi Gunasekara","orcid":"0000-0002-3750-2309","position":4,"is_corresponding":false},{"id":667865,"name":"Young-Mee Kim","orcid":"0000-0001-6616-2393","position":5,"is_corresponding":false},{"id":1537888,"name":"Adriana Zimnicka","orcid":null,"position":6,"is_corresponding":false},{"id":1537889,"name":"Misuk Bae","orcid":null,"position":7,"is_corresponding":false},{"id":646807,"name":"Ke Ma","orcid":"0000-0003-1436-3673","position":8,"is_corresponding":false},{"id":1537890,"name":"Peter T. Toth","orcid":null,"position":9,"is_corresponding":false},{"id":897205,"name":"Ying Hu","orcid":"0000-0002-6870-8991","position":10,"is_corresponding":false},{"id":1537891,"name":"Ayesha N. Shajahan-Haq","orcid":null,"position":11,"is_corresponding":false},{"id":561511,"name":"Hemal H. Patel","orcid":"0000-0001-6722-9625","position":12,"is_corresponding":false},{"id":647755,"name":"Saverio Gentile","orcid":"0009-0001-3870-3305","position":13,"is_corresponding":false},{"id":461400,"name":"Marcelo G. Bonini","orcid":"0000-0003-1193-1428","position":14,"is_corresponding":false},{"id":235204,"name":"Jalees Rehman","orcid":"0000-0002-2787-9292","position":15,"is_corresponding":false},{"id":940013,"name":"Yiyao Liu","orcid":"0000-0002-7222-739X","position":16,"is_corresponding":false},{"id":461401,"name":"Richard D. Minshall","orcid":"0000-0003-3164-475X","position":17,"is_corresponding":false},{"id":1409988,"name":"Ying Jiang","orcid":"0000-0002-2644-3964","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy","abstract":"As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here we show that knockdown of the membrane-inserted scaffolding and structural protein caveolin-1 (Cav-1) and expression of tyrosine 14 phospho-defective Cav-1 mutant (Y14F), as opposed to phospho-mimicking Y14D, altered mitochondrial morphology, and increased mitochondrial matrix mixing, mitochondrial fusion and fission dynamics as well as mitophagy in MDA-MB-231 triple negative breast cancer cells. Further, we found that interaction of Cav-1 with mitochondrial fusion/fission machinery Mitofusin 2 (Mfn2) and Dynamin related protein 1 (Drp1) was enhanced by Y14D mutant indicating Cav-1 Y14 phosphorylation prevented Mfn2 and Drp1 translocation to mitochondria. Moreover, limiting mitochondrial recruitment of Mfn2 diminished formation of the PINK1/Mfn2/Parkin complex required for initiation of mitophagy resulting in accumulation of damaged mitochondria and ROS (mtROS). Thus, these studies indicate that phospho-Cav-1 may be an important switch mechanism in cancer cell survival which could lead to novel strategies for complementing cancer therapies.","is_dataset_classified":null,"base_score":5.209486152841421,"endowment":5.209486152841421,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35413643","pmcid":"PMC9018165","openalex_id":"https://openalex.org/W4223453953","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL060678","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL007829","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL142636","title":null},{"funder_name":"BLRD VA","grant_id":"I01 BX001963","title":null},{"funder_name":"European Hematology Association","grant_id":"TRTH200","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL126516","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL139439","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01HL142636-02","title":"Fibroblast Mediated Mechanisms of Pulmonary Hypertension"},{"funder_name":"National Institutes of Health","grant_id":"5P01HL060678-07","title":"G Protein Regulation of Endothelial Barrier Function"},{"funder_name":"National Institutes of Health","grant_id":"5T32HL007829-28","title":"Training Program in Lung Biology and Pathobiology"},{"funder_name":"National Institutes of Health","grant_id":"5T32HL139439-04","title":"Training Program in Personalized Cardiovascular Medicine (TPIPCVM)"},{"funder_name":"National Institutes of Health","grant_id":"1R01HL126516-01","title":"Integration Free IPS Cells-Derived Progenitors for Cardiac Regeneration"}],"total_grants":12,"fwci":15.7067,"citation_percentile":0.99718283,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":25},{"year":2024,"count":45},{"year":2025,"count":69},{"year":2026,"count":38}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.redox.2022.102304","host_type":"journal"},{"url":"https://doi.org/10.1016/j.redox.2022.102304","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213231722000763?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213231722000763?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35413643","host_type":"repository"},{"url":"https://doaj.org/article/5ff54eba886243c59a38ab64bfa4363d","host_type":"repository"},{"url":"https://escholarship.org/uc/item/6s0784dg","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9018165","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9018165","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9018165?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.redox.2022.102304","host_type":""},{"url":"https://escholarship.org/content/qt6s0784dg/qt6s0784dg.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.redox.2022.102304","host_type":""}],"fields_of_study":["Caveolin-1 and cellular processes","Mitochondrial Function and Pathology","RNA modifications and cancer","0301 basic medicine","03 medical and health sciences","0303 health sciences","Caveolin 1","Mitochondria","Mitochondrial Dynamics","Mitochondrial Proteins","Mitophagy","Reactive Oxygen Species"],"mesh_terms":["Mitochondria","Reactive Oxygen Species","Mitochondrial Proteins","Caveolin 1","Mitochondrial Dynamics","Mitophagy"],"keywords":["MFN2","Mitophagy","Mitochondrial fission","mitochondrial fusion","PINK1","Cell biology","Parkin","MFN1","Mitochondrion","Biology","DNM1L","Mitochondrial DNA","Autophagy","Apoptosis","Biochemistry","Mtros","Mitochondrial Dynamics","Cav-1","Dynamin-related Protein 1","Mitofusin 2","570","Medicine (General)","QH301-705.5","Caveolin 1","610","Medical Biochemistry and Metabolomics","Mitochondrial Proteins","R5-920","Breast Cancer","Medicinal and biomolecular chemistry","2.1 Biological and endogenous factors","Biology (General)","Cancer","Pharmacology and Pharmaceutical Sciences","Biological Sciences","Mitochondria","Biochemistry and cell biology","Women's Health","Reactive Oxygen Species","Research Paper"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:51:52.770555Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}