{"doi":"10.1016/j.redox.2021.102208","title":"Identification of novel neutrophil very long chain plasmalogen molecular species and their myeloperoxidase mediated oxidation products in human sepsis","abstract":"Plasmalogens are a class of phospholipids containing vinyl ether linked aliphatic groups at the sn-1 position. Plasmalogens are known to contain 16- and 18-carbon aliphatic groups at the sn-1 position. Here, we reveal that the human neutrophil plasmenylethanolamine pool uniquely includes molecular species with very long carbon chain (VLC) aliphatic groups, including 20-, 22- and 24-carbon vinyl ether linked aliphatic groups at the sn-1 position. We identified these novel VLC plasmalogen species by electrospray ionization mass spectrometry methods. VLC plasmalogens were only found in the neutrophil plasmenylethanolamine pool. During neutrophil activation, VLC plasmenylethanolamines undergo myeloperoxidase-dependent oxidation to produce VLC 2-chlorofatty aldehyde and its oxidation product, 2-chlorofatty acid (2-ClFA). Furthermore, plasma concentrations of VLC 2-ClFA are elevated in human sepsis. These studies demonstrate for the first time VLC plasmenylethanolamine molecular species, their myeloperoxidase-mediated chlorolipid products and the presence of these chlorolipids in human sepsis.","journal":"Redox Biology","year":2021,"id":180834,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":730430,"name":"Matthew J. Jellinek","orcid":"0000-0002-5076-360X","position":1,"is_corresponding":false},{"id":730951,"name":"Megan P. Kilroy","orcid":null,"position":2,"is_corresponding":false},{"id":380619,"name":"Carolyn J. Albert","orcid":"0000-0002-7946-3934","position":3,"is_corresponding":false},{"id":729802,"name":"Valerio Rasi","orcid":"0000-0001-5727-6188","position":4,"is_corresponding":false},{"id":251513,"name":"Daniel F. Hoft","orcid":"0000-0002-8921-4093","position":5,"is_corresponding":false},{"id":442246,"name":"M.G.S. Shashaty","orcid":"0000-0002-8766-3418","position":6,"is_corresponding":false},{"id":105482,"name":"Nuala J. Meyer","orcid":"0000-0003-4597-5584","position":7,"is_corresponding":false},{"id":380621,"name":"David A. Ford","orcid":"0000-0002-0029-1560","position":8,"is_corresponding":false},{"id":635832,"name":"Kaushalya Amunugama","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:47:57.268805Z","pmid":"34902676","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}