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Focus is on new schemes of classification and the importance of ANCAs in the diagnosis and prognosis of these systemic vasculitides. Current therapeutic strategies consisting of glucocorticoids in conjunction with conventional or biologic agents for both induction of remission and remission maintenance are outlined. Future research directions include investigation of the optimal duration and frequency of maintenance therapy and development of targeted therapeutic agents.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25399936","pmcid":null,"openalex_id":"https://openalex.org/W1912084238","authors":[],"funders":[],"total_grants":0,"fwci":2.2189,"citation_percentile":0.87231471,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":6},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0889857X14000921?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0889857X14000921?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.rdc.2014.09.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25399936","host_type":"repository"}],"fields_of_study":["Vasculitis and related conditions","Coagulation, Bradykinin, Polyphosphates, and Angioedema","Urticaria and Related Conditions","Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","Antibodies, Antineutrophil Cytoplasmic","Autoantibodies","Churg-Strauss Syndrome","Enzyme-Linked Immunosorbent Assay","Glucocorticoids","Granulomatosis with Polyangiitis","Humans","Immunosuppressive Agents","Maintenance Chemotherapy","Microscopic Polyangiitis","Myeloblastin","Peroxidase","Remission Induction"],"mesh_terms":["Autoantibodies","Enzyme-Linked Immunosorbent Assay","Glucocorticoids","Humans","Immunosuppressive Agents","Peroxidase","Remission Induction","Granulomatosis with Polyangiitis","Churg-Strauss Syndrome","Antibodies, Antineutrophil Cytoplasmic","Myeloblastin","Microscopic Polyangiitis","Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","Maintenance Chemotherapy"],"keywords":["Medicine","Microscopic polyangiitis","Granulomatosis with polyangiitis","Anti-neutrophil cytoplasmic antibody","Eosinophilic","Vasculitis","Maintenance therapy","Systemic vasculitis","Biologic Agents","Immunology","Pathology","Internal medicine","Disease","Chemotherapy","Anca-associated Vasculitis","Granulomatosis With Polyangiitis (Wegener)","Eosinophilic Granulomatosis With Polyangiitis (Churg-strauss)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T21:34:49.254239Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}