{"doi":"10.1016/j.rbmo.2022.01.001","title":"Blastocyst versus cleavage embryo transfer improves cumulative live birth rates, time and cost in oocyte recipients: a randomized controlled trial","abstract":null,"journal":"Reproductive BioMedicine Online","year":2022,"id":619754,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1599569,"name":"Ignacio Rodríguez","orcid":null,"position":1,"is_corresponding":false},{"id":1599570,"name":"Gemma Arroyo","orcid":null,"position":2,"is_corresponding":false},{"id":1599571,"name":"Annalisa Racca","orcid":null,"position":3,"is_corresponding":false},{"id":1599572,"name":"Francisca Martínez","orcid":null,"position":4,"is_corresponding":false},{"id":35918,"name":"Nikolaos P. Polyzos","orcid":"0000-0001-6161-0011","position":5,"is_corresponding":false},{"id":1599568,"name":"Elisabet Clua","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Blastocyst versus cleavage embryo transfer improves cumulative live birth rates, time and cost in oocyte recipients: a randomized controlled trial","abstract":"<h4>Research question</h4>Does embryo transfer day (day 5 versus day 3) affect cumulative live birth rates (CLBR), time to live birth (TLB) and cost per live birth (CPL) in recipients of donated oocytes?<h4>Study design</h4>A single-centre RCT conducted between April 2017 and August 2018. Recipients of donated oocytes were randomized to cleavage-stage (day 3) or to blastocyst-stage (day 5) embryo transfer. Eligible recipients were aged 18-50 years and in their first or second synchronous cycle. Primary outcome was CLBR (12 months from first embryo transfer), and fresh and subsequent cryopreserved transfers were considered; TLB and CPL were also analysed.<h4>Results</h4>Recipients (n = 134) were randomized to the day-3 group (n = 69) or to the day-5 group (n = 65). Day-5 transfer resulted in a 15.9% relative increase in CLBR and a significant shorter TLB compared with day-3 transfer. To reach a 50% CLBR, the day-3 group required 6 months more than the day-5 group (15.3 versus 8.9 months, respectively). The average CPL in the day-3 strategy cost 24% more than the day-5 strategy (€14817.10 versus €10959.20). Clinical pregnancy rate was 25% less in the day-3 group. The trial was prematurely stopped after poor initial results in the day-3 arm led to unplanned interim analysis.<h4>Conclusions</h4>The transfer of blastocyst-stage embryos in recipients of donated oocytes is preferred as it leads to a higher clinical pregnancy rate, live birth rate, shorter time to pregnancy and lower costs to achieve live birth, compared with cleavage-stage embryo transfer.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35430119","pmcid":null,"openalex_id":"https://openalex.org/W4205177573","authors":[],"funders":[],"total_grants":0,"fwci":4.6582,"citation_percentile":0.95104388,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":7},{"year":2024,"count":8},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1472648322000281?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1472648322000281?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.rbmo.2022.01.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35430119","host_type":"repository"}],"fields_of_study":["Reproductive Health and Technologies","Reproductive Biology and Fertility","Assisted Reproductive Technology and Twin Pregnancy"],"mesh_terms":["Birth Rate","Blastocyst","Embryo Transfer","Female","Fertilization in Vitro","Humans","Oocytes","Pregnancy","Retrospective Studies","Pregnancy Rate","Live Birth"],"keywords":["Blastocyst Transfer","Live birth","Embryo transfer","Medicine","Randomized controlled trial","Pregnancy rate","Pregnancy","Single Embryo Transfer","Gynecology","Blastocyst","Obstetrics","Andrology","Embryo","Biology","Internal medicine","Embryogenesis","oocyte donation","Cumulative Live Birth Rate","Time To Live Birth","Blastocyst Stage Embryo Transfer (D5)","Cleavage Stage Embryo Transfer (D3)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T08:21:54.999870Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}