{"doi":"10.1016/j.puhe.2023.11.027","title":"Mediating pathways that link adverse childhood experiences with cardiovascular disease","abstract":null,"journal":"Public Health","year":2024,"id":632020,"datarank":0.5775677751536143,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.21788348423385862,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.21788348423385862,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":10,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1385089,"name":"Efthalia Massou","orcid":"0000-0003-0488-482X","position":1,"is_corresponding":false},{"id":235718,"name":"Michael P. Kelly","orcid":"0000-0002-2029-5841","position":2,"is_corresponding":false},{"id":1638138,"name":"J.A. Ford","orcid":null,"position":3,"is_corresponding":false},{"id":1638136,"name":"A.L. Carr","orcid":"0000-0002-3497-1943","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mediating pathways that link adverse childhood experiences with cardiovascular disease","abstract":"<h4>Objectives</h4>There is uncertainty about which factors mediate the association between adverse childhood experiences (ACEs) and cardiovascular disease (CVD). This could inform secondary prevention targets.<h4>Study design</h4>Mediation analysis of a prospective cohort study.<h4>Methods</h4>English Longitudinal Study of Ageing (ELSA) wave 3 data (2006/7) were used to measure retrospective exposure to 12 individual ACEs and waves 2 to 4 (2004/5 to 2008/9) data to measure current exposure to potential mediators [smoking, physical activity, alcohol consumption, body mass index, depression, and C-reactive protein (CRP)]. Waves 4 to 9 ELSA data (2008/9 to 2018/19) were used to measure incident CVD. Cumulative ACE exposure was categorised into experiencing 0, 1 to 3, or ≥4 individual ACEs. Associations were tested between ACE categories, potential mediators, and incident CVD, to inform which variables were analysed in causal mediation models.<h4>Results</h4>The analytical cohort consisted of 4547 participants (56% women), with a mean age of 64 years (standard deviation = 9 years). At least one ACE had been experienced by 45% of the cohort, and 24% developed incident CVD over a median follow-up period of 9.7 years (interquartile range: 5.3-11.4 years). After adjusting for potential confounders, experiencing ≥4 ACEs compared with none was associated with incident CVD [odds ratio (OR): 1.55; 95% confidence interval (CI): 1.10, 2.17], and the association of one to three ACEs compared with none was non-significant (OR: 1.08; 95% CI: 0.93, 1.24). There were two statistically significant mediators of the association between ≥4 ACEs and incident CVD: CRP and depression, which accounted for 10.7% and 10.8% of the association, respectively.<h4>Conclusions</h4>Inflammation and depression partially mediated the association between ACEs and CVD. Targeting these factors may reduce the future incidence of CVD.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38134567","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute on Aging","grant_id":"R01AG017644","title":null},{"funder_name":"National Institute for Health and Care Research","grant_id":"198-1074","title":null},{"funder_name":"Economic and Social Research Council","grant_id":"","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.puhe.2023.11.027","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0033350623004572?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0033350623004572?httpAccept=text/plain","host_type":"publisher"},{"url":"https://www.repository.cam.ac.uk/bitstreams/b2d26975-f5b7-44fe-ae3b-5fa666b2bc3f/download","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Humans","Cardiovascular Diseases","Retrospective Studies","Longitudinal Studies","Prospective Studies","Depression","Middle Aged","Female","Male","Adverse Childhood Experiences"],"keywords":["Depression","Inflammation","Cardiovascular disease","Health Behaviours","Mediation Analysis","Adverse Childhood Experiences"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T01:25:42.983125Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}