{"doi":"10.1016/j.pt.2024.07.003","title":"Pass the boron: benzoxaboroles as antiparasite drugs","abstract":null,"journal":"Trends in Parasitology","year":2024,"id":653973,"datarank":0.413541990542669,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.06815422659356207,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.06815422659356207,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":8,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1503448,"name":"David Horn","orcid":"0000-0001-5173-9284","position":1,"is_corresponding":false},{"id":314783,"name":"Mark C. Field","orcid":"0000-0002-4866-2885","position":2,"is_corresponding":false},{"id":314775,"name":"Martin Zoltner","orcid":"0000-0002-0214-285X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pass the boron: benzoxaboroles as antiparasite drugs","abstract":"The development of new drug modalities has been facilitated recently by the introduction of boron as a component of organic compounds, and specifically within a benzoxaborale scaffold. This has enabled exploration of new chemical space and the development of effective compounds targeting a broad range of morbidities, including infections by protozoa, fungi, worms, and bacteria. Most notable is the recent demonstration of a single oral dose cure using acoziborole against African trypanosomiasis. Common and species-/structure-specific interactions between benzoxaboroles and parasite species have emerged and provide vital insights into the mechanisms of cidality, as well as potential challenges in terms of resistance and/or side effects. Here, we discuss the literature specific to benzoxaborole studies in parasitic protists and consider unanswered questions concerning this important new drug class.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39107181","pmcid":null,"openalex_id":"https://openalex.org/W4401322108","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"204697/Z/16/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"217105/Z/19/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":4,"fwci":3.6637,"citation_percentile":0.93735669,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S147149222400179X/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S147149222400179X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S147149222400179X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S147149222400179X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.pt.2024.07.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39107181","host_type":"repository"},{"url":"https://discovery.dundee.ac.uk/en/publications/ede64d51-e59a-4732-a3c5-aac3ddf728d7","host_type":"repository"},{"url":"https://discovery.dundee.ac.uk/files/145000500/PIIS147149222400179X.pdf","host_type":"repository"},{"url":"https://discovery.dundee.ac.uk/ws/files/145000500/PIIS147149222400179X.pdf","host_type":"repository"}],"fields_of_study":["Parasitic Infections and Diagnostics","Trypanosoma species research and implications","Cardiac Structural Anomalies and Repair","Animals","Boron Compounds","Antiparasitic Agents","Humans","Boron"],"mesh_terms":["Animals","Antiparasitic Agents","Boron","Boron Compounds","Humans"],"keywords":["Biology","Protozoa","Drug","Drug resistance","Neglected tropical diseases","Drug development","Computational biology","Intensive care medicine","Microbiology","Pharmacology","Medicine","Pathology","Disease","Drugs","Mode of action","parasites","Benzoxaborole","Leurs","Cpsf Complex"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T02:31:36.056678Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}