{"doi":"10.1016/j.pt.2022.02.008","title":"No sweet deal: the antibody-mediated immune response to malaria","abstract":null,"journal":"Trends in Parasitology","year":2022,"id":609355,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1131740,"name":"Mary Lopez-Perez","orcid":"0000-0002-9876-0248","position":1,"is_corresponding":false},{"id":1431447,"name":"Mads Delbo Larsen","orcid":"0000-0002-1985-5901","position":2,"is_corresponding":false},{"id":308475,"name":"Gestur Vidarsson","orcid":"0000-0001-5621-003X","position":3,"is_corresponding":false},{"id":918447,"name":"Lars Hviid","orcid":"0000-0002-1698-4927","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"No sweet deal: the antibody-mediated immune response to malaria","abstract":"IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum malaria, and the PfEMP1 adhesins expressed on the surface of the infected erythrocytes are crucial immunological targets. The antigen specificity of these antibodies has therefore been a major research focus. However, we recently reported that the Fc domain of naturally induced PfEMP1-specific IgG1 is selectively modified by post-translational omission of fucose from the conserved Fc glycan. The resulting afucosylated IgG has increased affinity for the IgG-Fc-receptor III family (FcγRIII), found on natural killer cells and on subsets of other cells in the immune system. We discuss the implications of these findings for the basic understanding of antimalarial immunity and for the design of improved vaccines against the disease.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35279381","pmcid":null,"openalex_id":"https://openalex.org/W4220851881","authors":[],"funders":[{"funder_name":"Landsteiner Foundation for Blood Transfusion Research","grant_id":"1721","title":null},{"funder_name":"Danish International Development Agency","grant_id":"17-02-KU","title":null},{"funder_name":"Danish International Development Agency","grant_id":"BSU3-UG","title":null},{"funder_name":"Sundhed og Sygdom, Det Frie Forskningsråd","grant_id":"013400123B","title":null}],"total_grants":4,"fwci":1.9523,"citation_percentile":0.85325304,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":8},{"year":2026,"count":2}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://pure.amsterdamumc.nl/files/176689138/No-sweet-deal.pdf","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/files/176689138/No-sweet-deal.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1471492222000381?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1471492222000381?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pure.amsterdamumc.nl/en/publications/6779dcd4-9269-45d3-916b-876168c6a314","host_type":"repository"},{"url":"https://doi.org/10.1016/j.pt.2022.02.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35279381","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/no-sweet-deal(b1df8c0b-7e39-4ba9-8c13-b64d2653ac64).html","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/422285","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/fb5d4edf-5b61-466c-abd2-e8135a624530","host_type":"repository"}],"fields_of_study":["Monoclonal and Polyclonal Antibodies Research","vaccines and immunoinformatics approaches","Malaria Research and Control","Adaptive Immunity","Antibodies, Protozoan","Antigens, Protozoan","Erythrocytes","Humans","Immunoglobulin G","Malaria, Falciparum","Plasmodium falciparum","Protozoan Proteins"],"mesh_terms":["Antibodies, Protozoan","Antigens, Protozoan","Erythrocytes","Humans","Immunoglobulin G","Plasmodium falciparum","Protozoan Proteins","Malaria, Falciparum","Adaptive Immunity"],"keywords":["Malaria","Immune system","Immunology","Virology","Antibody","Malaria vaccine","Biology","Antibody response","Plasmodium falciparum","Medicine","Fucosylation","Acquired Immunity","Plasmodium Falciparum Malaria","Fcγ Receptors","Fc Region","Antibody Effector Function"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T06:47:07.665449Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}