{"doi":"10.1016/j.prostaglandins.2004.09.010","title":"Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics","abstract":null,"journal":"Prostaglandins & Other Lipid Mediators","year":2005,"id":610517,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289434,"name":"Sheldon Milstien","orcid":"0000-0003-0728-837X","position":1,"is_corresponding":false},{"id":289435,"name":"Sarah Spiegel","orcid":"0000-0003-0751-2634","position":2,"is_corresponding":false},{"id":618524,"name":"Michael Maceyka","orcid":"0000-0003-4635-3496","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics","abstract":"It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival. Given the interconvertibility of these two opposing signaling molecules, it is essential that any study that examines the effects of one also look at the other. The newly available technology of liquid chromatography-tandem mass spectroscopy (LC-MS/MS) is increasingly being applied for this purpose, as it can quickly identify and measure many different sphingolipids simultaneously. An added benefit of LC-MS/MS is that it is several orders of magnitude more sensitive than enzymatic methods or more traditional chromatographic techniques, allowing smaller sample sizes and increased throughput. Here, we briefly discuss the importance of LC-MS/MS for measuring sphingolipid metabolites and some future directions researchers may take given the increasingly accessibility to this technology.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16099387","pmcid":null,"openalex_id":"https://openalex.org/W2061672786","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01CA61774","title":null}],"total_grants":1,"fwci":1.5869,"citation_percentile":0.81599812,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1098882304001005?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1098882304001005?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.prostaglandins.2004.09.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16099387","host_type":"repository"}],"fields_of_study":["Sphingolipid Metabolism and Signaling","Lipid Membrane Structure and Behavior","Cellular transport and secretion"],"mesh_terms":["Sphingosine Kinase","Animals","Cell Survival","Ceramides","Chromatography, Liquid","Humans","Lipids","Lysophospholipids","Models, Biological","Mass Spectrometry","Sphingolipids","Sphingosine","Signal Transduction","Apoptosis","Phosphotransferases (Alcohol Group Acceptor)","Cell Proliferation"],"keywords":["Sphingolipid","Sphingosine","Sphingosine kinase","Ceramide","Sphingosine-1-phosphate","Chemistry","Metabolite","Kinase","Lipid signaling","Biochemistry","Cell signaling","Signal transduction","Apoptosis","Enzyme","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T22:51:39.800245Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}