{"doi":"10.1016/j.polymer.2025.128653","title":"Bioactive, PDMS-containing shape memory composite scaffolds with accelerated degradation rates","abstract":"A self-fitting scaffold could enable a regenerative engineering approach to treat irregular craniomaxillofacial bone defects. We have previously reported conformally fitting, shape memory polymer (SMP) scaffolds based on poly(ε-caprolactone) (PCL). The fitting temperature (i.e., melt temperature, T m ) was tuned based on PCL architecture: linear -PCL-diacrylate ( linear -PCL-DA; T m = ∼55 °C) or star -PCL-tetraacrylate ( star -PCL-TA, T m = ∼45 °C). Scaffolds were also formed as semi-interpenetrating networks (semi-IPNs) by incorporating thermoplastic poly(L-lactic acid) (PLLA). The inclusion of a polydimethylsiloxane-dimethacrylate (PDMS-DMA) macromer and 45S5 Bioglass® (BG) were independently shown to promote hydroxyapatite (HAp) mineralization as well as to accelerate degradation. In this study, PDMS-containing, composite SMP scaffolds were prepared with varying macromer compositions and BG concentrations. PCL/PDMS co-matrix scaffolds were formed with linear -PCL-DA or star -PCL-TA and PDMS-DMA (75:25 wt%). PCL/PLLA/PDMS (75:12.5:12.5 wt%) co-matrix-semi-IPNs were also formed. BG was included at relatively low concentrations (5 and 10 wt%). Composite scaffolds were fabricated to concentrate BG on the pore walls via a modified solvent cast particulate leaching (SCPL) approach with a fused BG/salt template. PDMS-containing scaffolds preserved shape memory behavior and were non-brittle. In vitro degradation rates were accelerated for PDMS-containing composite scaffolds, owing to a combination of phase separation of polymer components and hydrophilicity imparted by the BG. Additionally, robust bioactivity was observed for PDMS-containing composite scaffolds with HAp mineralization commencing in just 1 day (1X simulated body fluid; SBF).","journal":"Polymer","year":2025,"id":541398,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1222441,"name":"MaryGrace N. Wahby","orcid":null,"position":1,"is_corresponding":false},{"id":1222442,"name":"Kaylee M. Breining","orcid":null,"position":2,"is_corresponding":false},{"id":434354,"name":"Melissa A. Grunlan","orcid":"0000-0002-5428-0461","position":3,"is_corresponding":false},{"id":966768,"name":"Brandon M. Nitschke","orcid":"0009-0007-8463-210X","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:52:47.161928Z","pmid":"42245470","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}