{"doi":"10.1016/j.pnpbp.2009.12.014","title":"Measuring behavior in mice with chronic stress depression paradigm","abstract":null,"journal":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","year":2010,"id":616374,"datarank":0.8027787200214102,"base_score":5.351858133476067,"endowment":5.351858133476067,"self_citation_contribution":0.8027787200214102,"citation_network_contribution":0.0,"self_endowment_contribution":0.8027787200214102,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":210,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":172252,"name":"Harry W.M. Steinbusch","orcid":null,"position":1,"is_corresponding":false},{"id":277321,"name":"Tatyana Strekalova","orcid":"0000-0001-9937-5600","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Measuring behavior in mice with chronic stress depression paradigm","abstract":"Many studies with chronic stress, a common depression paradigm, lead to inconsistent behavioral results. We are introducing a new model of stress-induced anhedonia, which provides more reproducible induction and behavioral measuring of depressive-like phenotype in mice. First, a 4-week stress procedure induces anhedonia, defined by decreased sucrose preference, in the majority of but not all C57BL/6 mice. The remaining 30-50% non-anhedonic animals are used as an internal control for stress effects that are unrelated to anhedonia. Next, a modified sucrose test enables the detection of inter-individual differences in mice. Moreover, testing under dimmed lighting precludes behavioral artifacts caused by hyperlocomotion, a major confounding factor in stressed mice. Finally, moderation of the stress load increases the reproducibility of anhedonia induction, which otherwise is difficult to provide because of inter-batch variability in laboratory mice. We believe that our new mouse model overcomes some major difficulties in measuring behavior with chronic stress depression models.","is_dataset_classified":null,"base_score":5.351858133476067,"endowment":5.351858133476067,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20026369","pmcid":null,"openalex_id":"https://openalex.org/W2061994498","authors":[],"funders":[],"total_grants":0,"fwci":1.2799,"citation_percentile":0.76239962,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":13},{"year":2014,"count":13},{"year":2015,"count":10},{"year":2016,"count":14},{"year":2017,"count":9},{"year":2018,"count":11},{"year":2019,"count":9},{"year":2020,"count":11},{"year":2021,"count":10},{"year":2022,"count":25},{"year":2023,"count":18},{"year":2024,"count":18},{"year":2025,"count":20},{"year":2026,"count":11}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0278584609004254?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0278584609004254?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.pnpbp.2009.12.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20026369","host_type":"repository"},{"url":"https://cris.maastrichtuniversity.nl/en/publications/24601f06-3cf3-43c0-84c7-1148ea080fe4","host_type":"repository"}],"fields_of_study":["Stress Responses and Cortisol","Tryptophan and brain disorders","Neuroendocrine regulation and behavior"],"mesh_terms":["Animals","Avoidance Learning","Behavior, Animal","Choice Behavior","Disease Models, Animal","Drinking Behavior","Exploratory Behavior","Feeding Behavior","Food Preferences","Male","Mice, Inbred C57BL","Motor Activity","Stress, Psychological","Sucrose","Sweetening Agents","Swimming","Time Factors","Statistics, Nonparametric","Maze Learning","Hindlimb Suspension","Mice","Rats"],"keywords":["Anhedonia","Chronic stress","Depression (economics)","Confounding","Moderation","Psychology","Stress (linguistics)","Preference","Social defeat","Neuroscience","Clinical psychology","Medicine","Internal medicine","Social psychology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:43:26.409345Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}