{"doi":"10.1016/j.pneurobio.2015.03.005","title":"The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors","abstract":null,"journal":"Progress in Neurobiology","year":2015,"id":662819,"datarank":0.8902341293429383,"base_score":5.934894195619588,"endowment":5.934894195619588,"self_citation_contribution":0.8902341293429383,"citation_network_contribution":0.0,"self_endowment_contribution":0.8902341293429383,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":377,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1724470,"name":"Roberto I. Melendez","orcid":null,"position":1,"is_corresponding":false},{"id":1730434,"name":"Laszlo Zaborszky","orcid":null,"position":2,"is_corresponding":false},{"id":378511,"name":"T. Celeste Napier","orcid":"0000-0003-4399-1513","position":3,"is_corresponding":false},{"id":265966,"name":"David H. Root","orcid":"0000-0002-1927-2175","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors","abstract":"The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally relevant stimuli and coherent adaptive behaviors.","is_dataset_classified":null,"base_score":5.934894195619588,"endowment":5.934894195619588,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25857550","pmcid":"PMC4687907","openalex_id":"https://openalex.org/W2092075435","authors":[],"funders":[{"funder_name":"USPHSGs","grant_id":"NS23945","title":null},{"funder_name":"USPHSGs","grant_id":"DA05255","title":null},{"funder_name":"USPHSGs","grant_id":"DA015760","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA019783","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA021475","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA024923","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS023945","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA006886","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA023306","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA019783","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA021475","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA015760","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA026252","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F32 DA05651","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA024923","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA026252","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"RF1 NS023945","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA0331231","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA023306","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA006886","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"F30 MH45180","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F31 DA019763","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F32 DA005651","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA005255","title":null},{"funder_name":"Intramural Research Program at the National Institute on Drug Abuse (DHR)","grant_id":"","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":27,"fwci":10.7089,"citation_percentile":0.99330201,"influential_citations":0,"citation_trend":[{"year":2015,"count":4},{"year":2016,"count":21},{"year":2017,"count":16},{"year":2018,"count":42},{"year":2019,"count":40},{"year":2020,"count":57},{"year":2021,"count":34},{"year":2022,"count":33},{"year":2023,"count":41},{"year":2024,"count":42},{"year":2025,"count":31},{"year":2026,"count":16}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4687907","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4687907","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0301008215000271?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301008215000271?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.pneurobio.2015.03.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25857550","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neurotransmitter Receptor Influence on Behavior","Neural dynamics and brain function","Animals","Basal Forebrain","Behavior, Animal","GABAergic Neurons","Humans","Motivation","Motor Activity","Nucleus Accumbens"],"mesh_terms":["Animals","Behavior, Animal","Humans","Motivation","Motor Activity","Nucleus Accumbens","GABAergic Neurons","Basal Forebrain"],"keywords":["Neuroscience","Ventral pallidum","Nucleus accumbens","GABAergic","Psychology","Ventral tegmental area","Medium spiny neuron","Subthalamic nucleus","Lateral hypothalamus","Addiction","Thalamus","Biology","Basal ganglia","Inhibitory postsynaptic potential","Deep brain stimulation","Hypothalamus","Central nervous system","Medicine","Dopamine","Globus pallidus","Glutamate","GABA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T17:35:42.644288Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}