{"doi":"10.1016/j.plefa.2019.08.002","title":"Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis","abstract":null,"journal":"Prostaglandins, Leukotrienes and Essential Fatty Acids","year":2019,"id":688855,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1158276,"name":"Alexandre Leuci","orcid":"0000-0001-9329-8165","position":1,"is_corresponding":false},{"id":1799625,"name":"Blandine Dizier","orcid":null,"position":2,"is_corresponding":false},{"id":1799626,"name":"Tiphaine Belleville-Rolland","orcid":null,"position":3,"is_corresponding":false},{"id":1799627,"name":"Alexandre Mansour","orcid":null,"position":4,"is_corresponding":false},{"id":1799628,"name":"Fanny Martin","orcid":null,"position":5,"is_corresponding":false},{"id":1799629,"name":"Dominique Pidard","orcid":null,"position":6,"is_corresponding":false},{"id":1624157,"name":"Pascale Gaussem","orcid":null,"position":7,"is_corresponding":false},{"id":1799630,"name":"Christilla Bachelot-Loza","orcid":null,"position":8,"is_corresponding":false},{"id":1799624,"name":"Benoit Decouture","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis","abstract":"Discrepancies in preclinical studies of aspirin (ASA) antiplatelet activity in mouse models of bleeding and arterial thrombosis led us to evaluate commonly reported methods in order to propose a procedure for reliably measuring the effects of single dose ASA on mouse hemostasis. FVB and C57Bl6 mice received 100 mg/kg of ASA or vehicle orally 30 min or 3 h prior to investigate either hemostasis using the tail bleeding assay or carotid thrombosis induced by FeCl<sub>3</sub>, or to blood sampling for isolated platelet aggregation and TXB<sub>2</sub> generation. Expected inhibition of COX1 by ASA was ascertained by a strong decrease in TXB<sub>2</sub> production, and its effect on platelet function and hemostasis, by decreased collagen-induced aggregation and increased bleeding time, respectively. Strikingly, we determined that anti-hemostatic effects of ASA were more predictable 30 min after administration than 3 h later. Conversely, ASA did not alter time to arterial occlusion of the carotid upon FeCl<sub>3</sub>-induced thrombosis, suggesting ASA not to be used as reference inhibitor drug in this model of arterial thrombosis.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31442897","pmcid":null,"openalex_id":"https://openalex.org/W2968384601","authors":[],"funders":[{"funder_name":"Institut National de la Santé et de la Recherche Médicale","grant_id":"","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.1508089,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0952327819300742?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0952327819300742?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.plefa.2019.08.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31442897","host_type":"repository"},{"url":"https://inserm.hal.science/inserm-02355824","host_type":"repository"}],"fields_of_study":["Antiplatelet Therapy and Cardiovascular Diseases","Inflammatory mediators and NSAID effects","Venous Thromboembolism Diagnosis and Management","Animals","Aspirin","Disease Models, Animal","Drug Evaluation, Preclinical","Hemorrhage","Hemostasis","Male","Mice","Mice, Inbred C57BL","Platelet Aggregation","Platelet Aggregation Inhibitors","Platelet Function Tests","Thrombosis"],"mesh_terms":["Animals","Aspirin","Disease Models, Animal","Drug Evaluation, Preclinical","Hemorrhage","Hemostasis","Male","Mice, Inbred C57BL","Platelet Aggregation","Platelet Aggregation Inhibitors","Platelet Function Tests","Thrombosis","Mice"],"keywords":["Hemostasis","Bleeding time","Aspirin","Medicine","Platelet","Thrombosis","Pharmacology","Antiplatelet drug","Anesthesia","Clopidogrel","Platelet aggregation","Internal medicine","Platelets","preclinical study"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T19:51:17.750143Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}