{"doi":"10.1016/j.plefa.2017.06.007","title":"Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood","abstract":null,"journal":"Prostaglandins, Leukotrienes and Essential Fatty Acids","year":2017,"id":640561,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1664822,"name":"Annika I. Ostermann","orcid":null,"position":1,"is_corresponding":false},{"id":1664824,"name":"Lisa Stork","orcid":null,"position":2,"is_corresponding":false},{"id":1664825,"name":"Sabrina Fritzsch","orcid":null,"position":3,"is_corresponding":false},{"id":1664826,"name":"Heike Kohrs","orcid":null,"position":4,"is_corresponding":false},{"id":1664828,"name":"Theresa Greupner","orcid":null,"position":5,"is_corresponding":false},{"id":861666,"name":"Andreas Hahn","orcid":"0000-0001-8459-6582","position":6,"is_corresponding":false},{"id":843461,"name":"Nils Helge Schebb","orcid":"0000-0003-1299-6629","position":7,"is_corresponding":false},{"id":861663,"name":"Jan Philipp Schuchardt","orcid":"0000-0003-1724-6325","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood","abstract":"<h4>Introduction</h4>EPA and DHA cause different physiological effects, which are in many cases mediated via their oxidative metabolites (oxylipins). However, metabolism studies investigating the effect of either EPA or DHA on comprehensive oxylipin patterns are lacking.<h4>Material and methods</h4>The short and long term (1, 3, 6, and 12 week) effect of 1076mg/d DHA (free of EPA) on free (unesterified) oxylipin concentrations in plasma and lipopolysacharid (LPS) stimulated blood of 12 healthy men (mean age 25.1 ± 1.5 years) was investigated.<h4>Results</h4>After DHA supplementation, plasma levels of all DHA-oxylipins (HDHAs, EpDPEs, DiHDPEs) significantly increased (up to 600%) in a time-dependent fashion. Oxylipins of EPA and arachidonic acid (AA) were also affected. Whereas a slight increase in several EPA-derived hydroxy-FAs (including the RvE1 precursor 18-HEPE) and dihydroxy-FAs was observed after DHA supplementation, a trend to a slight decline in AA-derived oxylipin levels was found. In LPS stimulated blood, it is shown that DHA supplementation significantly reduces the ability of immune cells to form AA-derived COX (TXB2 and PGB2) and 12-LOX (12-HETE) eicosanoids. While no increase in EPA COX metabolites was found, n-3 PUFA 12-LOX metabolites of EPA (12-HEPE) and DHA (14-HDHA) were highly induced.<h4>Conclusion</h4>We demonstrated that DHA supplementation causes a time-dependent shift in the entire oxylipin profile suggesting a cross-linked metabolism of PUFAs and subsequent formation of oxygenated lipid mediators.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28651702","pmcid":null,"openalex_id":"https://openalex.org/W2624982586","authors":[],"funders":[{"funder_name":"German Research Foundation","grant_id":"SCHE 1801","title":null},{"funder_name":"German Research Foundation","grant_id":"SCHU 2516","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":2.2851,"citation_percentile":0.87333446,"influential_citations":0,"citation_trend":[{"year":2018,"count":5},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":6},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":6},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0952327817301199?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0952327817301199?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.plefa.2017.06.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28651702","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.plefa.2017.06.007","host_type":""}],"fields_of_study":["Eicosanoids and Hypertension Pharmacology","Fatty Acid Research and Health","Microbial metabolism and enzyme function","0301 basic medicine","0303 health sciences","03 medical and health sciences","12-Hydroxy-5,8,10,14-eicosatetraenoic Acid","Adult","Arachidonic Acid","C-Reactive Protein","Dietary Supplements","Docosahexaenoic Acids","Eicosanoids","Fatty Acids, Unsaturated","Germany","Humans","Inflammation","Leukocyte Count","Lipopolysaccharides","Male","Oxylipins","Young Adult"],"mesh_terms":["Adult","C-Reactive Protein","Docosahexaenoic Acids","Fatty Acids, Unsaturated","Germany","Humans","Inflammation","Leukocyte Count","Lipopolysaccharides","Male","Eicosanoids","Arachidonic Acid","12-Hydroxy-5,8,10,14-eicosatetraenoic Acid","Dietary Supplements","Oxylipins","Young Adult"],"keywords":["Oxylipin","Polyunsaturated fatty acid","Arachidonic acid","Metabolism","Docosahexaenoic acid","Chemistry","Immune system","Thromboxanes","Biochemistry","Internal medicine","Endocrinology","Biology","Fatty acid","Immunology","Medicine","Enzyme","DHA","EPA","Lipid Mediators","Lc N-3 Pufa","Free Oxylipins","Immune Cell Stimulation","Adult","Inflammation","Lipopolysaccharides","Male","Docosahexaenoic Acids","Leukocyte Count","Young Adult","C-Reactive Protein","Germany","Dietary Supplements","Fatty Acids, Unsaturated","Eicosanoids","Humans","12-Hydroxy-5,8,10,14-eicosatetraenoic Acid","Oxylipins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T12:42:54.757866Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}