{"doi":"10.1016/j.placenta.2020.12.006","title":"Placental magnetic resonance imaging in chronic hypertension: A case-control study","abstract":"INTRODUCTION: We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS: In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T Ingenia scanner. T2-weighted images, diffusion weighted and T1/T2* relaxometry data was acquired. Placental T2*, T1 and apparent diffusion coefficient (ADC) maps were calculated. RESULTS: 129 women (43 with chronic hypertension and 86 uncomplicated pregnancies) were imaged at a median of 27.7 weeks' gestation (interquartile range (IQR) 23.9-32.1) and 28.9 (IQR 26.1-32.9) respectively. Visual analysis of T2-weighted imaging demonstrated placentae to be either appropriate for gestation or to have advanced lobulation in women with chronic hypertension, resulting in a greater range of placental mean T2* values for a given gestation, compared to gestation-matched controls. Both skew and kurtosis (derived from histograms of T2* values across the whole placenta) increased with advancing gestational age at imaging in healthy pregnancies; women with chronic hypertension had values overlapping those in the control group range. Upon visual assessment, the mean ADC declined in the third trimester, with a corresponding decline in placental mean T2* values and showed an overlap of values between women with chronic hypertension and the control group. DISCUSSION: A combined placental MR examination including T2 weighted imaging, T2*, T1 mapping and diffusion imaging demonstrates varying placental phenotypes in a cohort of women with chronic hypertension, showing overlap with the control group.","journal":"Placenta","year":2020,"id":68072,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":360900,"name":"Jana Hutter","orcid":"0000-0003-3476-3500","position":1,"is_corresponding":false},{"id":360901,"name":"Paddy J. Slator","orcid":"0000-0001-6967-989X","position":2,"is_corresponding":false},{"id":360902,"name":"Laurence H. Jackson","orcid":"0000-0002-5904-8012","position":3,"is_corresponding":false},{"id":360903,"name":"Paul T. Seed","orcid":"0000-0001-7904-7933","position":4,"is_corresponding":false},{"id":360904,"name":"Laura McCabe","orcid":"0000-0001-9369-8839","position":5,"is_corresponding":false},{"id":362642,"name":"Mudher Al‐Adnani","orcid":null,"position":6,"is_corresponding":false},{"id":362643,"name":"Andreas Marnerides","orcid":null,"position":7,"is_corresponding":false},{"id":362644,"name":"Simi George","orcid":null,"position":8,"is_corresponding":false},{"id":360905,"name":"Lisa Story","orcid":"0000-0001-9328-9592","position":9,"is_corresponding":false},{"id":250913,"name":"Joseph V. Hajnal","orcid":"0000-0002-2690-5495","position":10,"is_corresponding":false},{"id":360906,"name":"Mary Rutherford","orcid":"0000-0003-3361-1337","position":11,"is_corresponding":false},{"id":89779,"name":"Lucy C. Chappell","orcid":"0000-0001-6219-3379","position":12,"is_corresponding":false},{"id":360899,"name":"Alison Ho","orcid":"0000-0003-3293-4476","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"33341490","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}