{"doi":"10.1016/j.plabm.2021.e00202","title":"Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease","abstract":null,"journal":"Practical Laboratory Medicine","year":2021,"id":617938,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":839652,"name":"Yoshiyasu Minami","orcid":"0000-0003-2745-9682","position":1,"is_corresponding":false},{"id":1593784,"name":"Takuya Hashimoto","orcid":null,"position":2,"is_corresponding":false},{"id":1593785,"name":"Junya Ako","orcid":null,"position":3,"is_corresponding":false},{"id":1593781,"name":"Masahiro Katamine","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease","abstract":"OBJECTIVES: Patients with familial hypercholesterolemia (FH) are at a very high risk of coronary artery diseases. The aim of the present study was to clarify the characteristics of coronary plaque in patients with FH. DESIGN: and Methods: A total of 569 patients who underwent optical coherence tomography (OCT) imaging of culprit plaque were included. The characteristics of culprit plaque were compared between patients with and without FH. RESULTS: A total of 38 patients (6.7%) were clinically diagnosed with FH. The location of the culprit plaque was significantly different (p ​< ​0.001) with a trend toward higher frequency of left main lesion in the FH group than in the group with no FH (7.9 vs. 0%). Culprit plaque was significantly shorter in patients with FH than those without FH (28.1 vs. 33.2 ​mm, p ​= ​0.016). A trend toward higher prevalence of plaque with macrophage accumulation in patients with FH than those without FH (50.0 vs. 34.7%, p ​= ​0.056) was observed, although the prevalence of other vulnerable characteristics including thin-cap fibroatheroma (TCFA) was comparable between patients with and without FH. Among patients with FH, significant increases in the prevalence of lipid-rich plaque (p ​= ​0.028) and TCFA (p ​= ​0.003) were observed according to the increase in low-density lipoprotein cholesterol (LDL-C) levels. CONCLUSIONS: Patients with FH had shorter culprit plaque without significant difference in the prevalence of vulnerable plaque components compared with patients without FH. A higher LDL-C level was associated with higher prevalence of vulnerable plaque in patients with FH.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33659602","pmcid":"PMC7895842","openalex_id":"https://openalex.org/W3123753205","authors":[],"funders":[],"total_grants":0,"fwci":1.0128,"citation_percentile":0.73919188,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S2352551721000020/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S2352551721000020/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352551721000020?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352551721000020?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.plabm.2021.e00202","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33659602","host_type":"repository"},{"url":"https://doaj.org/article/05134be928aa4ff4b2a417ffc2c99f5e","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7895842","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7895842","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7895842?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Lipoproteins and Cardiovascular Health","Coronary Interventions and Diagnostics","Cardiac Imaging and Diagnostics"],"mesh_terms":[],"keywords":["Culprit","Medicine","Vulnerable plaque","Internal medicine","Coronary artery disease","Cardiology","Fibrous cap","Familial hypercholesterolemia","Lesion","Gastroenterology","Cholesterol","Pathology","Myocardial infarction","Low-density Lipoprotein Cholesterol","optical coherence tomography"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:01:06.286213Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}