{"doi":"10.1016/j.pjnns.2017.08.007","title":"Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease","abstract":null,"journal":"Neurologia i Neurochirurgia Polska","year":2017,"id":637225,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1654419,"name":"Monika Gradzik","orcid":null,"position":1,"is_corresponding":false},{"id":1654420,"name":"Magda Fliszkiewicz","orcid":null,"position":2,"is_corresponding":false},{"id":1654421,"name":"Andrzej Kulesza","orcid":null,"position":3,"is_corresponding":false},{"id":1654422,"name":"Marek Gołębiowski","orcid":null,"position":4,"is_corresponding":false},{"id":242633,"name":"Leszek Pączek","orcid":"0000-0003-0160-3009","position":5,"is_corresponding":false},{"id":1654418,"name":"Mariusz Niemczyk","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease","abstract":"Autosomal-dominant polycystic kidney disease (ADPKD) is a relatively frequent genetic disorder that is associated with increased prevalence of intracranial aneurysms (IAs). However, evidence on the natural history of IAs in ADPKD is suboptimal. That leads to difficulties in development of recommendations on surveillance on patients with IAs in their medical history, or the need for repeat imaging for IAs in those with a negative result of the initial screening. The aim of the article is to present our experience on the natural history of IAs in ADPKD patients. MATERIAL AND METHODS: Thirty-four ADPKD patients, managed at our outpatient department, with imaging for intracranial aneurysms performed at least twice, were included into present retrospective analysis. RESULTS: Among 8 patients with an IA in their medical history, no new IA was observed during 93 patient-years of follow-up. In 6 patients with untreated, unruptured IAs, IA growth was observed in 2 cases during 32 patient-years of follow-up. Finally, among 20 patients with a negative result of initial screening, 2 new IAs were noticed during 115 patient-years of follow-up, including 1 patient with a positive family history for an IA, and 1 patient without a family history. CONCLUSIONS: Our observations support repeat imaging for IAs in patients with ADPKD, positive family history of IA, and negative result of initial screening. Additionally, efforts should be made to develop clinical and/or laboratory risk factors for IAs development in ADPKD patients without family history of IA, which enable to identify patients who should undergo repeat imaging for IAs.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28843770","pmcid":null,"openalex_id":"https://openalex.org/W2750253740","authors":[],"funders":[],"total_grants":0,"fwci":1.2024,"citation_percentile":0.81238951,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0028384317302529?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0028384317302529?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.pjnns.2017.08.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28843770","host_type":"repository"}],"fields_of_study":["Genetic and Kidney Cyst Diseases","Cerebrospinal fluid and hydrocephalus","Abdominal vascular conditions and treatments","Adult","Aged","Female","Humans","Intracranial Aneurysm","Male","Middle Aged","Polycystic Kidney Diseases"],"mesh_terms":["Adult","Aged","Intracranial Aneurysm","Female","Humans","Polycystic Kidney Diseases","Male","Middle Aged"],"keywords":["Medicine","Autosomal dominant polycystic kidney disease","Natural history","Family history","Polycystic kidney disease","Medical history","Disease","Past medical history","Pediatrics","Aneurysm","Kidney disease","Internal medicine","Surgery","Intracranial aneurysm","Magnetic Resonance Imaging"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:34:46.726789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}