{"doi":"10.1016/j.phro.2024.100653","title":"Reduced-distortion diffusion weighted imaging for head and neck radiotherapy","abstract":"Background and purpose Quantitative Diffusion Weighted Imaging (DWI) has potential value in guiding head and neck (HN) cancer radiotherapy. However, clinical translation has been hindered by severe distortions in standard single-shot Echo-Planar-Imaging (ssEPI) and prolonged scan time and low SNR in Turbo-Spin-Echo (ssTSE) sequences. In this study, we evaluate \"multi-shot\" (ms) msEPI and msTSE acquisitions in the context of HN radiotherapy. Materials and methods ssEPI, ssTSE, msEPI with 2 and 3 shots (2sEPI, 3sEPI), and msTSE DWI were acquired in a phantom, healthy volunteers (N=10), and patients with HN cancer (N=5) on a 3-Tesla wide-bore MRI in radiotherapy simulation RF coil setup, with matched spatial resolution (2x2x5mm) and b = 0, 200, 800 s/mm 2 . Geometric distortions measured with deformable vector field (DVF) and contour analysis, apparent diffusion coefficient (ADC) values, and signal-to-noise-ratio efficiency (SNR eff ) were quantified for all scans. Results All techniques significantly (P<1x10 -3 ) reduced distortions compared with ssEPI (DVF mean = 3.1 ± 1.3 mm). Distortions were marginally lower for msTSE (DVF mean = 1.5 ± 0.6 mm) than ssTSE (1.8 ± 0.9 mm), but were slightly higher with 2sEPI and 3sEPI (2.6 ± 1.0 mm, 2.2 ± 1.0 mm). SNR eff reduced with decreasing distortion with ssEPI=21.9 ± 7.9, 2sEPI=15.1 ± 5.0, 3sEPI=12.1 ± 4.5, ssTSE=6.0 ± 1.6, and msTSE=5.7 ± 1.9 for b = 0 images. Phantom ADC values were consistent across all protocols (errors ≤ 0.03x10 -3 mm 2 /s), but in vivo ADC values were ∼ 4 % lower with msEPI and ∼ 12 % lower with ssTSE/msTSE compared with ssEPI. Conclusions msEPI and TSE acquisitions exhibited improved geometric distortion at the cost of SNR eff and scan time. While msTSE exhibited the least distortion, 3sEPI may offer an appealing middle-ground with improved geometric fidelity but superior efficiency and in vivo ADC quantification.","journal":"Physics and Imaging in Radiation Oncology","year":2024,"id":469261,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255789,"name":"Ramesh Paudyal","orcid":"0000-0003-0302-211X","position":1,"is_corresponding":false},{"id":728547,"name":"Alex Dresner","orcid":"0000-0002-0469-6012","position":2,"is_corresponding":false},{"id":255808,"name":"Amita Shukla‐Dave","orcid":"0000-0001-7456-3197","position":3,"is_corresponding":false},{"id":255810,"name":"Nancy Y. Lee","orcid":"0000-0003-3044-9522","position":4,"is_corresponding":false},{"id":724497,"name":"Laura Cerviño","orcid":"0000-0001-6479-6990","position":5,"is_corresponding":false},{"id":783447,"name":"Ricardo Otazo","orcid":"0000-0002-3782-4930","position":6,"is_corresponding":false},{"id":728546,"name":"Victoria Yu","orcid":"0000-0003-4559-9670","position":7,"is_corresponding":false},{"id":338798,"name":"Eric Aliotta","orcid":"0000-0002-7666-0254","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:05:28.027781Z","pmid":"39399877","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}