{"doi":"10.1016/j.phro.2023.01.001","title":"Association of cardiac calcium burden with overall survival after radiotherapy for non-small cell lung cancer","abstract":"Background and purpose: Coronary calcifications are associated with coronary artery disease in patients undergoing radiotherapy (RT) for non-small cell lung cancer (NSCLC). We quantified calcifications in the coronary arteries and aorta and investigated their relationship with overall survival (OS) in patients treated with definitive RT (Def-RT) or post-operative RT (PORT). Materials and methods: ), while the DL estimator ranged from 0 (no plaque) to 3 (high plaque). Patient and treatment characteristics were explored for association with OS. Results: (HR:1.06 (95%CI:1.02-1.11); p = 0.03), and poor Karnofsky Performance Status (HR: 0.97 (95%CI: 0.94-0.99); p = 0.03) were associated with worse OS. No relationship was identified between the plaque volumes and OS in PORT, or between the DL plaque estimator and OS in either Def-RT or PORT. Conclusions: Coronary artery calcification assessed from RT planning CT scans was significantly associated with OS in patients who underwent Def-RT for NSCLC. This HU thresholding method can be straightforwardly implemented such that the role of calcifications can be further explored.","journal":"Physics and Imaging in Radiation Oncology","year":2023,"id":363363,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":103872,"name":"Aditya Apte","orcid":"0000-0001-8120-0669","position":1,"is_corresponding":false},{"id":250702,"name":"Andrew Jackson","orcid":"0000-0001-8701-6387","position":2,"is_corresponding":false},{"id":250701,"name":"Ellen Yorke","orcid":"0000-0003-2604-3140","position":3,"is_corresponding":false},{"id":497224,"name":"Anthony F. Yu","orcid":"0000-0002-7120-8285","position":4,"is_corresponding":false},{"id":269964,"name":"Andrew J. Plodkowski","orcid":"0000-0002-3772-370X","position":5,"is_corresponding":false},{"id":245117,"name":"Abraham J. Wu","orcid":"0000-0002-2597-7091","position":6,"is_corresponding":false},{"id":1117827,"name":"Ariel Peleg","orcid":null,"position":7,"is_corresponding":false},{"id":433782,"name":"Mohammed Al‐Sadawi","orcid":"0000-0003-3064-7887","position":8,"is_corresponding":false},{"id":363893,"name":"Michelle Iocolano","orcid":"0000-0002-6125-0754","position":9,"is_corresponding":false},{"id":325305,"name":"Daphna Y. Gelblum","orcid":"0000-0001-7211-6246","position":10,"is_corresponding":false},{"id":325302,"name":"Narek Shaverdian","orcid":"0000-0002-0294-8749","position":11,"is_corresponding":false},{"id":245107,"name":"Charles B. Simone","orcid":"0000-0002-0867-3694","position":12,"is_corresponding":false},{"id":241186,"name":"Andreas Rimner","orcid":"0000-0002-1214-3856","position":13,"is_corresponding":false},{"id":325306,"name":"Daniel R. Gomez","orcid":"0000-0002-1839-9510","position":14,"is_corresponding":false},{"id":325304,"name":"Annemarie F. Shepherd","orcid":"0000-0002-4469-0889","position":15,"is_corresponding":false},{"id":309736,"name":"Maria Thor","orcid":null,"position":16,"is_corresponding":false},{"id":434504,"name":"J. Haseltine","orcid":"0000-0003-1341-4918","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:14:28.054440Z","pmid":"36687507","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}