{"doi":"10.1016/j.peptides.2015.04.027","title":"What is the real relevance of endogenous ghrelin?","abstract":null,"journal":"Peptides","year":2015,"id":687640,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463121,"name":"Miguel López","orcid":"0000-0002-7823-1648","position":1,"is_corresponding":false},{"id":909340,"name":"Johan Fernø","orcid":"0000-0002-4598-2955","position":2,"is_corresponding":false},{"id":463119,"name":"Carlos Diéguez","orcid":"0000-0002-0919-4337","position":3,"is_corresponding":false},{"id":260308,"name":"Rubén Nogueiras","orcid":"0000-0002-9976-9930","position":4,"is_corresponding":false},{"id":1796430,"name":"Omar Al Massadi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"What is the real relevance of endogenous ghrelin?","abstract":"Ghrelin is a pleiotropic and ubiquitous gastric hormone implicated in body physiology. Ghrelin exhibits potent orexigenic actions and increases body weight and adiposity. Ghrelin is also involved in other metabolic functions among which we can highlight the GH releasing activity and the regulation of glucose homeostasis. Ghrelin needs the enzyme GOAT to be acylated, a step essential for binding to the GHSR1a receptor to exert its functions. Genetic animal models emerge as important tools to delineate the physiological relevance of ghrelin on energy balance. Despite the numerous reports using different genetically engineered mouse models targeting the ghrelin system, its endogenous relevance in metabolism seems to be less important than its pharmaceutical options.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26003396","pmcid":null,"openalex_id":"https://openalex.org/W209761738","authors":[],"funders":[{"funder_name":"Ministerio de Economia y Competitividad","grant_id":"BFU2012-35255","title":null},{"funder_name":"Xunta de Galicia","grant_id":"EM 2012/039","title":null},{"funder_name":"Xunta de Galicia","grant_id":"2012-CP069","title":null},{"funder_name":"Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn)","grant_id":"","title":null}],"total_grants":4,"fwci":1.377,"citation_percentile":0.76580634,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":5},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://hdl.handle.net/20.500.11940/1344","host_type":"repository"},{"url":"http://hdl.handle.net/20.500.11940/1344","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0196978115001485?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196978115001485?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.peptides.2015.04.027","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26003396","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Biochemical Analysis and Sensing Techniques","Adipose Tissue and Metabolism","Animals","Body Weight","Energy Metabolism","Ghrelin","Glucose","Homeostasis","Humans","Mice","Obesity","Receptors, Ghrelin"],"mesh_terms":["Animals","Body Weight","Energy Metabolism","Glucose","Homeostasis","Humans","Obesity","Mice","Ghrelin","Receptors, Ghrelin"],"keywords":["Ghrelin","Orexigenic","Endogeny","Endocrinology","Energy homeostasis","Internal medicine","Hormone","Biology","Homeostasis","Receptor","Medicine","Obesity","Neuropeptide","Neuropeptide Y receptor","Goat","Glucose Homeostasis","Mouse Mutants","Ghsr1a"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T22:23:55.835405Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}