{"doi":"10.1016/j.peptides.2011.07.003","title":"Physiological roles revealed by ghrelin and ghrelin receptor deficient mice","abstract":null,"journal":"Peptides","year":2011,"id":669760,"datarank":2.1882337329459594,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":1.5817760427707765,"self_endowment_contribution":0.6064576901751826,"citer_contribution":1.5817760427707765,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":53,"citers_with_citation_signal":44,"citers_with_endowment":44,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484733,"name":"Yuxiang Sun","orcid":"0000-0002-6656-3733","position":1,"is_corresponding":false},{"id":120202,"name":"Roy G. Smith","orcid":null,"position":2,"is_corresponding":false},{"id":1749260,"name":"Rosie G. Albarran-Zeckler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Physiological roles revealed by ghrelin and ghrelin receptor deficient mice","abstract":"Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21781995","pmcid":"PMC3221867","openalex_id":"https://openalex.org/W1964349298","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG029740","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG019230","title":null}],"total_grants":2,"fwci":1.7569,"citation_percentile":0.82348321,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":7},{"year":2014,"count":4},{"year":2015,"count":6},{"year":2016,"count":1},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221867","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221867","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0196978111002786?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196978111002786?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.peptides.2011.07.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21781995","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Biochemical Analysis and Sensing Techniques","Adipose Tissue and Metabolism","Animals","Central Nervous System","Dopaminergic Neurons","Energy Metabolism","Female","Gastric Mucosa","Ghrelin","Glucose","Humans","Learning","Leptin","Longevity","Male","Memory","Mice","Mice, Knockout","Models, Animal","Neuroprotective Agents","Receptors, Ghrelin","Signal Transduction"],"mesh_terms":["Animals","Central Nervous System","Energy Metabolism","Female","Gastric Mucosa","Glucose","Humans","Learning","Longevity","Male","Memory","Signal Transduction","Mice, Knockout","Neuroprotective Agents","Leptin","Models, Animal","Mice","Ghrelin","Receptors, Ghrelin","Dopaminergic Neurons"],"keywords":["Ghrelin","Orexigenic","Receptor","Growth hormone secretagogue receptor","Endocrinology","Internal medicine","Obestatin","Hormone","Biology","Immune system","Medicine","Neuropeptide Y receptor","Neuropeptide","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T03:43:12.675440Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}