{"doi":"10.1016/j.peptides.2007.07.032","title":"The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria","abstract":null,"journal":"Peptides","year":2008,"id":676004,"datarank":1.9290688872444361,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":1.3684184445019307,"self_endowment_contribution":0.5606504427425053,"citer_contribution":1.3684184445019307,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":35,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1766331,"name":"Gert Simonet","orcid":null,"position":1,"is_corresponding":false},{"id":1766334,"name":"Bert Breugelmans","orcid":null,"position":2,"is_corresponding":false},{"id":1206330,"name":"Sofie Van Soest","orcid":null,"position":3,"is_corresponding":false},{"id":1766338,"name":"Vincent Van Hoef","orcid":null,"position":4,"is_corresponding":false},{"id":1554412,"name":"Jozef Vanden Broeck","orcid":"0000-0001-7653-0516","position":5,"is_corresponding":false},{"id":1766329,"name":"Vanessa Franssens","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria","abstract":"The prophenoloxidase-activating system is an important component of the innate immune response of insects, involved in wound healing and melanotic encapsulation. In this paper we show that in the desert locust, Schistocerca gregaria, hemocytes, challenged with microbial elicitors, are indispensable for the limited proteolytic activation of prophenoloxidase (proPO) in plasma. In addition, we assessed the influence of serine protease inhibitors on the induction of PO-activity in plasma. While soybean Bowman-Birk inhibitor (SBBI) inhibited the PO activation by laminarin-treated hemocytes, the endogenous pacifastin-related inhibitors, SGPI-1 (S. gregaria pacifastin-related inhibitor-1) and SGPI-2 did not affect the PO-activity under similar conditions. On the other hand, real-time PCR analysis revealed that the transcripts, encoding SGPI-1-3, were more abundant in the fat body of immune challenged animals, as compared to control animals.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18207608","pmcid":null,"openalex_id":"https://openalex.org/W2015764882","authors":[],"funders":[],"total_grants":0,"fwci":1.5517,"citation_percentile":0.82190242,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0196978107004901","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0196978107004901","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196978107004901?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196978107004901?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.peptides.2007.07.032","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18207608","host_type":"repository"},{"url":"http://linkinghub.elsevier.com/retrieve/pii/S0196-9781(07)00490-1","host_type":"repository"},{"url":"https://lirias.kuleuven.be/retrieve/1c4f28f6-641a-4619-89d7-39944213b5df","host_type":"repository"}],"fields_of_study":["Invertebrate Immune Response Mechanisms","Aquaculture disease management and microbiota","Neurobiology and Insect Physiology Research","Animals","Catechol Oxidase","Chymotrypsin","Dose-Response Relationship, Drug","Enzyme Activation","Enzyme Precursors","Fat Body","Female","Gene Expression","Glucans","Grasshoppers","Hemocytes","Hemolymph","Host-Pathogen Interactions","Humans","Insect Proteins","Lipopolysaccharides","Models, Biological","Peptides","Polysaccharides","Serine Proteinase Inhibitors","Trypsin Inhibitor, Bowman-Birk Soybean","Trypsin Inhibitors"],"mesh_terms":["Animals","Chymotrypsin","Catechol Oxidase","Dose-Response Relationship, Drug","Enzyme Activation","Enzyme Precursors","Fat Body","Female","Glucans","Grasshoppers","Hemocytes","Hemolymph","Humans","Lipopolysaccharides","Models, Biological","Peptides","Polysaccharides","Trypsin Inhibitor, Bowman-Birk Soybean","Trypsin Inhibitors","Serine Proteinase Inhibitors","Gene Expression","Insect Proteins","Host-Pathogen Interactions"],"keywords":["Schistocerca","Desert locust","Prophenoloxidase","Protease","Biology","Serine protease","Pathogen","Locust","Ecology","Biochemistry","Microbiology","Enzyme","Innate immune system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:57:58.792604Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}