{"doi":"10.1016/j.patter.2022.100536","title":"Supervised dimensionality reduction for exploration of single-cell data by HSS-LDA","abstract":"classes, enabling the study of specific aspects of cellular heterogeneity. We implement feature selection by hybrid subset selection (HSS) and demonstrate that this computationally efficient approach generates non-stochastic, interpretable axes amenable to diverse biological processes such as differentiation over time and cell cycle. We benchmark HSS-LDA against several popular dimensionality-reduction algorithms and illustrate its utility and versatility for the exploration of single-cell mass cytometry, transcriptomics, and chromatin accessibility data.","journal":"Patterns","year":2022,"id":248965,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233122,"name":"David R. Glass","orcid":"0000-0001-9924-167X","position":1,"is_corresponding":false},{"id":233126,"name":"Reema Baskar","orcid":"0000-0002-3872-0164","position":2,"is_corresponding":false},{"id":255502,"name":"Inna Averbukh","orcid":"0000-0003-1863-205X","position":3,"is_corresponding":false},{"id":237486,"name":"Samuel C. Kimmey","orcid":"0000-0002-5742-4037","position":4,"is_corresponding":false},{"id":237484,"name":"Albert G. Tsai","orcid":"0000-0002-6607-3347","position":5,"is_corresponding":false},{"id":233119,"name":"Felix J. Hartmann","orcid":"0000-0002-4174-2276","position":6,"is_corresponding":false},{"id":233129,"name":"Sean C. Bendall","orcid":"0000-0003-1341-2453","position":7,"is_corresponding":false},{"id":296308,"name":"Meelad Amouzgar","orcid":"0000-0003-0521-9223","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T00:24:19.356023Z","pmid":"36033591","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}