{"doi":"10.1016/j.patbio.2007.09.019","title":"Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes","abstract":null,"journal":"Pathologie Biologie","year":2008,"id":591119,"datarank":0.6751075526741055,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.31542326175434987,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.31542326175434987,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":9,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512371,"name":"S. Haddouk","orcid":null,"position":1,"is_corresponding":false},{"id":1512372,"name":"Y.B. Hadj Hamida","orcid":null,"position":2,"is_corresponding":false},{"id":1512373,"name":"T. Kamoun","orcid":null,"position":3,"is_corresponding":false},{"id":1512374,"name":"M.B. Ayed","orcid":null,"position":4,"is_corresponding":false},{"id":1512375,"name":"M. Hachicha","orcid":null,"position":5,"is_corresponding":false},{"id":1512376,"name":"H. Masmoudi","orcid":null,"position":6,"is_corresponding":false},{"id":1512370,"name":"R. Fakhfakh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes","abstract":"We analyzed 86 children with newly diagnosed type 1 diabetes for antibodies to islet cells (ICA), glutamic acid decarboxylase (GADA), second-islet antigen (IA-2A), and insulin (IAA) in order to evaluate the prevalence of immune-mediated type 1 diabetes, as well as to recognize which autoantibody combination is more frequently associated with the disease. A positive result for one or more diabetes-related antibodies evaluated was found in 78 children (90.7%). With regard to single autoantibody testing, ICA were found to be positive in 49 patients (57%), GADA in 56 (65.1%), IA-2A in 37 (43%), and IAA in 43 (50%) patients. Combining the determination of at least two autoantibodies, GADA and/or IAA were better detectable than other antibody combination, being positive in 70 patients (81.4%). GADA and IA-2A represent also a useful screening combination; being positive in 65 patients (75.6%). Our data indicate that the vast majority of cases of type 1 diabetes in children may be considered as immune-mediated and that multiple autoantibody analysis improves identification of the disease.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18178035","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0369811407002325?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0369811407002325?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Pancreas","Islets of Langerhans","Humans","Diabetes Mellitus, Type 1","Glutamate Decarboxylase","Autoantibodies","Child","Tunisia"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T14:27:58.698891Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}