{"doi":"10.1016/j.pain.2009.04.013","title":"Differential regulation of TRP channels in a rat model of neuropathic pain","abstract":null,"journal":"Pain","year":2009,"id":652168,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1701154,"name":"Sandra Oerther","orcid":null,"position":1,"is_corresponding":false},{"id":1701155,"name":"Guilherme Lucas","orcid":null,"position":2,"is_corresponding":false},{"id":1031140,"name":"Jan P. Mattsson","orcid":"0009-0004-0674-0197","position":3,"is_corresponding":false},{"id":1625664,"name":"Patrik Ernfors","orcid":null,"position":4,"is_corresponding":false},{"id":1701153,"name":"Susanne Staaf","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Differential regulation of TRP channels in a rat model of neuropathic pain","abstract":"Neuropathic pain is a chronic disease resulting from dysfunction of the nervous system often due to peripheral nerve injury. Hypersensitivity to sensory stimuli (mechanical, thermal or chemical) is a common source of pain in patients and ion channels involved in detecting these stimuli are possible candidates for inducing and/or maintaining the pain. Transient receptor potential (TRP) channels expressed on nociceptors respond to different sensory stimuli and a few of them have been studied previously in the models of neuropathic pain. Using real-time PCR for quantification of all known TRP channels we identified several TRP channels, which have not been associated with nociception or neuropathic pain before, to be expressed in the DRG and to be differentially regulated after spared nerve injury (SNI). Of all TRP channel members, TRPML3 showed the most dramatic change in animals exhibiting neuropathic pain behaviour compared to control animals. In situ hybridisation showed a widespread increase of expression in neurons of small, medium and large cell sizes, indicating expression in multiple subtypes. Co-localisation of TRPML3 with CGRP, NF200 and IB4 staining confirmed a broad subtype distribution. Expression studies during development showed that TRPML3 is an embryonic channel that is induced upon nerve injury in three different nerve injury models investigated. Thus, the current results link for the first time a re-expression of TRPML3 with the development of neuropathic pain conditions. In addition, decreased mRNA levels after SNI were seen for TRPM6, TRPM8, TRPV1, TRPA1, TRPC3, TRPC4 and TRPC5.","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19446956","pmcid":null,"openalex_id":"https://openalex.org/W2090358427","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"232675","title":"Identification of a new mechanism of stem cell self-renewal; direct implications on self-repair and tumor initiating cells in the brain"},{"funder_name":"European Commission","grant_id":"223489","title":"Molecular mechanisms of neuronal restoration:  novel approaches for Parkinson's Disease"}],"total_grants":2,"fwci":3.6507,"citation_percentile":0.92993477,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":9},{"year":2014,"count":13},{"year":2015,"count":7},{"year":2016,"count":6},{"year":2017,"count":13},{"year":2018,"count":3},{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":7},{"year":2022,"count":6},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://zenodo.org/record/3421633","host_type":"repository"},{"url":"https://zenodo.org/record/3421633","host_type":"repository"},{"url":"https://www.ovid.com/00006396-200907000-00031","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.pain.2009.04.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19446956","host_type":"repository"},{"url":"http://producao.usp.br/handle/BDPI/24417","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.pain.2009.04.013","host_type":""},{"url":"https://dx.doi.org/10.1016/j.pain.2009.04.013","host_type":""},{"url":"http://dx.doi.org/doi:10.1016/j.pain.2009.04.013","host_type":""}],"fields_of_study":["Ion Channels and Receptors","Pain Mechanisms and Treatments","Neurobiology and Insect Physiology Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Axotomy","Calcitonin Gene-Related Peptide","Disease Models, Animal","Female","Functional Laterality","Ganglia, Spinal","Gene Expression Regulation, Developmental","Hyperalgesia","Lectins","Male","Mice","Mice, Inbred BALB C","Neuralgia","Neurofilament Proteins","Neurons","Neuropeptide Y","Physical Stimulation","RNA, Messenger","Rats","Rats, Sprague-Dawley","TRPC Cation Channels","Time Factors"],"mesh_terms":["Animals","Disease Models, Animal","Female","Ganglia, Spinal","Hyperalgesia","Functional Laterality","Male","Mice, Inbred BALB C","Neuralgia","Neurons","Neuropeptide Y","Physical Stimulation","RNA, Messenger","Time Factors","Calcitonin Gene-Related Peptide","Neurofilament Proteins","Rats, Sprague-Dawley","Gene Expression Regulation, Developmental","Axotomy","Lectins","TRPC Cation Channels","Mice","Rats"],"keywords":["Neuropathic pain","Transient receptor potential channel","TRPV1","SNi","Nerve injury","Nociceptor","Nociception","Medicine","TRPM8","Neuroscience","TRPV4","Noxious stimulus","TRPC","Anesthesia","Internal medicine","Chemistry","Receptor","Biology","Male","Neurons","Mice, Inbred BALB C","Calcitonin Gene-Related Peptide","Gene Expression Regulation, Developmental","Axotomy","Functional Laterality","Rats","Disease Models, Animal","Mice","Hyperalgesia","Neurofilament Proteins","Ganglia, Spinal","Lectins","Physical Stimulation","Animals","Neuralgia","Female","Neuropeptide Y","RNA, Messenger"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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