{"doi":"10.1016/j.ostima.2025.100302","title":"STATIN USE AND LONGITUDINAL CHANGES IN KNEE MRI–DERIVED THREE-DIMENSIONAL BONE SHAPE: DATA FROM THE OSTEOARTHRITIS INITIATIVE","abstract":"INTRODUCTION Alterations in three-dimensional (3D) bone shape is strongly associated with progression of knee OA. Statins, widely used for lipid-lowering, have shown mixed effects on OA outcomes. OBJECTIVES To assess the impact of statin use on longitudinal changes in 3D bone shape in the Osteoarthritis Initiative (OAI) participants with Heberden’s nodes (HN + ), a hallmark of generalized OA, at baseline clinical examination. METHODS We conducted a longitudinal propensity score–matched (PSM) analysis of participants from the OAI. Participants without Heberden’s node (HN – ) or with traumatic knee injury, or missing data were excluded. PSM (1:1) was used to balance statin users and non-users on relevant demographic and clinical covariates. After matching, 412 knees were included (206 statin users and 206 non-users). 3D bone shape was quantified using the B-score, derived from knee MRI at baseline and Year 4, with higher scores indicating more OA-like shape. Longitudinal changes were evaluated using a linear mixed-effects model. The Reliable Change Index (RCI) was used to identify individuals with meaningful B-score changes. RESULTS Both groups showed significant within-group increases in B-scores from baseline to Year 4 (p < 0.001), indicating progression of OA-like shape over time. However, no significant between-group differences were observed at baseline (median [IQR]: 0.14 [–0.45, 0.90] vs. 0.15 [–0.60, 0.97]; p = 0.719) or Year 4 (0.37 [–0.44, 1.13] vs. 0.29 [–0.44, 1.11]; p = 0.666). Median 4-year B-score changes were also similar (0.12 [–0.02, 0.28] vs. 0.14 [0.02, 0.29]; p = 0.324). The proportion of individuals with meaningful B-score change did not differ significantly between groups (OR: 0.544; 95% CI: 0.179 to 1.653; p = 0.283). The difference in annual B-score change rate between groups was minimal and non-significant (0.003; 95% CI: –0.014 to 0.020; p = 0.747). No significant interactions were found with age, sex, BMI, or KL grade (all interaction p > 0.05). CONCLUSION Our study found no significant association between statin use and changes in 3D bone shape over four years in HN + OAI participants. While statins may have protective effects against certain aspects of OA pathology, their lack of impact on bone shape progression highlights the complexity of OA pathophysiology.","journal":"Osteoarthritis Imaging","year":2025,"id":569590,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9069,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1474775,"name":"Kamran Moradi","orcid":"0000-0001-9839-712X","position":1,"is_corresponding":false},{"id":313864,"name":"Ali Guermazi","orcid":"0000-0002-9374-8266","position":2,"is_corresponding":false},{"id":1475112,"name":"AS Brett","orcid":null,"position":3,"is_corresponding":false},{"id":1421665,"name":"F.W. Roemer","orcid":null,"position":4,"is_corresponding":false},{"id":242479,"name":"Shadpour Demehri","orcid":"0000-0001-5991-5924","position":5,"is_corresponding":false},{"id":1474774,"name":"Mehrdad Mahalleh","orcid":"0000-0002-6210-2112","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:57:03.510013Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}