{"doi":"10.1016/j.oret.2022.05.022","title":"Bacillary Detachment in Neovascular Age-Related Macular Degeneration","abstract":"OBJECTIVE: To evaluate the incidence of bacillary layer detachment among patients with neovascular age-related macular degeneration (nAMD) and their response to anti-VEGF therapy. DESIGN: Post hoc analysis of the OSPREY clinical trial, a prospective, double-masked, phase II study comparing 6-mg brolucizumab with 2-mg aflibercept over 56 weeks. PARTICIPANTS: Participants with treatment-naive nAMD at the initiation of the trial were included in the analysis (n = 81). METHODS: Spectral-domain OCT (SD-OCT) scans were obtained at 4-week intervals throughout the OSPREY study and were segmented automatically using a proprietary, machine learning-enabled higher-order feature-extraction platform. MAIN OUTCOME MEASURES: The presence of bacillary detachment, and in these eyes the effect of anti-VEGF therapy on change from baseline in visual acuity (VA), central subfield thickness (CST), retinal fluid volumes, subretinal hyper-reflective material (SHRM) volume, subretinal pigment epithelium (sub-RPE) fluid volume, and ellipsoid zone (EZ) integrity at week 56. RESULTS: Bacillary detachment was identified in 7.4% (6 of 81) eyes, which had higher fluid volumes, increased CST, EZ attenuation, and increased sub-RPE volume at baseline compared with eyes without bacillary detachment. Anti-VEGF treatment resulted in the resolution of bacillary detachment in 100% of the eyes. In eyes with bacillary detachment at baseline, the anti-VEGF treatment decreased CST, fluid burden, and SHRM volumes throughout the treatment course; however, there was no significant change from baseline in VA, sub-RPE volume, or EZ integrity throughout the 56-week course of anti-VEGF treatment. CONCLUSIONS: Bacillary detachment is an OCT signature that is identifiable in a notable proportion of nAMD eyes. Anti-VEGF therapy resulted in 100% resolution of bacillary detachment and significant decreases in CST and SHRM volume; however, improvements in VA may have been limited by persistent EZ attenuation.","journal":"Ophthalmology Retina","year":2022,"id":272774,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9074,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":939319,"name":"Kübra Sarıcı","orcid":"0000-0001-7088-4356","position":1,"is_corresponding":false},{"id":890435,"name":"Hasan Cetin","orcid":"0000-0001-9492-4957","position":2,"is_corresponding":false},{"id":476764,"name":"Leina Lunasco","orcid":"0000-0003-3403-7429","position":3,"is_corresponding":false},{"id":651659,"name":"Thuy Le","orcid":"0000-0002-2528-1692","position":4,"is_corresponding":false},{"id":363418,"name":"Duriye Damla Sevgi","orcid":"0000-0002-0395-8711","position":5,"is_corresponding":false},{"id":651657,"name":"Robert Zahid","orcid":"0000-0002-2679-2216","position":6,"is_corresponding":false},{"id":651658,"name":"Xiangyi Meng","orcid":"0000-0002-2034-4551","position":7,"is_corresponding":false},{"id":477959,"name":"Jamie Reese","orcid":null,"position":8,"is_corresponding":false},{"id":341327,"name":"Sunil K. Srivastava","orcid":"0000-0002-0398-8806","position":9,"is_corresponding":false},{"id":341328,"name":"Justis P. Ehlers","orcid":"0000-0001-6763-7768","position":10,"is_corresponding":false},{"id":890436,"name":"Sari Yordi","orcid":"0000-0002-9376-5840","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35654365","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}