{"doi":"10.1016/j.ophtha.2018.09.039","title":"Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration","abstract":null,"journal":"Ophthalmology","year":2019,"id":652916,"datarank":0.637274286307404,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":0.0,"self_endowment_contribution":0.637274286307404,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703452,"name":"Jason A. Alvarez","orcid":"0000-0001-8699-2781","position":1,"is_corresponding":false},{"id":1703453,"name":"Mohammad Yazdanie","orcid":null,"position":2,"is_corresponding":false},{"id":426218,"name":"Chandana Papudesu","orcid":"0000-0002-4753-6254","position":3,"is_corresponding":false},{"id":310781,"name":"Wai T. Wong","orcid":"0000-0003-0681-4016","position":4,"is_corresponding":false},{"id":466448,"name":"Henry E. Wiley","orcid":null,"position":5,"is_corresponding":false},{"id":1703454,"name":"Tiarnan D. Keenan","orcid":null,"position":6,"is_corresponding":false},{"id":54567,"name":"Emily Y. Chew","orcid":"0000-0003-0999-9802","position":7,"is_corresponding":false},{"id":258452,"name":"Frederick L. Ferris","orcid":"0000-0002-4933-0639","position":8,"is_corresponding":false},{"id":367380,"name":"Catherine A. Cukras","orcid":"0000-0002-1147-854X","position":9,"is_corresponding":false},{"id":1703451,"name":"Katherine G. Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration","abstract":"<h4>Purpose</h4>To investigate the natural history of dark adaptation (DA) function as measured by the change in rod intercept time (RIT) over 4 years and to correlate RIT change with age-related macular degeneration (AMD) severity.<h4>Design</h4>Longitudinal, single-center, observational study.<h4>Participants</h4>A total of 77 participants aged ≥50 years with a range of AMD severities.<h4>Methods</h4>Participants each contributing a single study eye to the analysis were assigned into person-based AMD severity groups based on fundus characteristics (drusen, pigmentary changes, late AMD, and subretinal drusenoid deposits [SDDs]). The DA function was assessed in study eyes at baseline and 3, 6, 12, 18, 24, 36, and 48 months. Mean change in DA function over time was calculated using the slope of linear regression fits of longitudinal RIT data. Patient-reported responses on a Low Luminance Questionnaire (LLQ) were obtained at baseline and yearly. Nonparametric statistical testing was performed on all comparisons.<h4>Main outcome measure</h4>The RIT, defined as the time taken after a photobleach for visual sensitivity to recover detection of a 5×10<sup>-3</sup> cd/m<sup>2</sup> stimulus (a decrease of 3 log units), was monitored in study eyes over 4 years, and the mean rate of change was computed.<h4>Results</h4>Longitudinal analysis of 65 study eyes followed on the standard testing protocol (mean age, 71±9.3 years; 49% were female) revealed that higher rates of RIT prolongation were correlated with AMD severity group assignment at baseline (P = 0.026) and with severity group assignments at year 4 (P = 0.0011). Study eyes that developed SDD during follow-up demonstrated higher rates of RIT prolongation relative to those that did not (P < 0.0001). Overall, higher rates of RIT prolongation were significantly correlated with greater 4-year decreases in LLQ scores (total mean score, P = 0.0032).<h4>Conclusions</h4>Longitudinal decline in DA function, which correlated with patient-reported functional deficits, was accelerated in eyes with greater AMD severity and especially in eyes with SDD both at baseline and at 4 years. The RIT prolongation as a measure of changing DA function may be a functional outcome measure in AMD clinical studies.","is_dataset_classified":null,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30278196","pmcid":"PMC8380039","openalex_id":"https://openalex.org/W2894389495","authors":[],"funders":[{"funder_name":"Intramural NIH HHS","grant_id":"Z99 EY999999","title":null},{"funder_name":"Doris Duke Charitable Foundation","grant_id":"","title":null},{"funder_name":"National Institutes of Health","grant_id":"","title":null},{"funder_name":"Colgate-Palmolive Company","grant_id":"","title":null},{"funder_name":"American Association for Dental Research","grant_id":"","title":null},{"funder_name":"NIH Medical Research Scholars Program","grant_id":"","title":null},{"funder_name":"National Eye Institute","grant_id":"","title":null}],"total_grants":7,"fwci":4.0603,"citation_percentile":0.9484169,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":9},{"year":2021,"count":12},{"year":2022,"count":12},{"year":2023,"count":7},{"year":2024,"count":5},{"year":2025,"count":12},{"year":2026,"count":6}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8380039","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8380039","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0161642018311217?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0161642018311217?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ophtha.2018.09.039","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30278196","host_type":"repository"}],"fields_of_study":["Ophthalmology and Visual Impairment Studies","Retinal Diseases and Treatments","Glaucoma and retinal disorders","Aged","Aged, 80 and over","Dark Adaptation","Female","Humans","Longitudinal Studies","Macular Degeneration","Male","Middle Aged","Outcome Assessment, Health Care","Retinal Drusen","Retinal Rod Photoreceptor Cells","Surveys and Questionnaires","Tomography, Optical Coherence","Visual Acuity"],"mesh_terms":["Aged","Aged, 80 and over","Dark Adaptation","Female","Humans","Longitudinal Studies","Macular Degeneration","Male","Middle Aged","Surveys and Questionnaires","Visual Acuity","Retinal Drusen","Outcome Assessment, Health Care","Retinal Rod Photoreceptor Cells","Tomography, Optical Coherence"],"keywords":["Medicine","Macular degeneration","Adaptation (eye)","Measure (data warehouse)","Ophthalmology","Optometry","Physical medicine and rehabilitation","Neuroscience"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:28:01.077292Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}