{"doi":"10.1016/j.onehlt.2025.100990","title":"Prevalence, antibiotic resistance, resistance and virulence determinants of Campylobacter jejuni in China: A systematic review and meta-analysis","abstract":null,"journal":"One Health","year":2025,"id":651562,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":646741,"name":"Hua Cai","orcid":"0000-0001-8747-6156","position":1,"is_corresponding":false},{"id":1699344,"name":"Biyao Xu","orcid":null,"position":2,"is_corresponding":false},{"id":1699345,"name":"Qingli Dong","orcid":null,"position":3,"is_corresponding":false},{"id":1699346,"name":"Kai Jia","orcid":null,"position":4,"is_corresponding":false},{"id":1406273,"name":"Zijie Lin","orcid":"0009-0000-1060-1916","position":5,"is_corresponding":false},{"id":752374,"name":"Xiang Wang","orcid":"0000-0001-9717-4936","position":6,"is_corresponding":false},{"id":1699347,"name":"Yangtai Liu","orcid":null,"position":7,"is_corresponding":false},{"id":1699348,"name":"Xiaojie Qin","orcid":null,"position":8,"is_corresponding":false},{"id":751349,"name":"Zhao Li","orcid":"0000-0002-9276-9129","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Prevalence, antibiotic resistance, resistance and virulence determinants of Campylobacter jejuni in China: A systematic review and meta-analysis","abstract":"Campylobacter jejuni ( C. jejuni ) is recognized as a serious food contaminant that extensively results in foodborne diseases. Numerous studies have been conducted on the prevalence and antibiotic resistance of C. jejuni , but there is a lack of comprehensive analysis of published data. This study provides a comprehensive overview of the epidemiology, antibiotic resistance, and virulence determinants of C. jejuni in China through a systematic review and meta-analysis. The prevalence levels of C. jejuni from low to high were the humans (5.2 %, 95 % CI: 4.2–6.4 %), foods (12.5 %, 95 % CI: 9.7–15.6 %), animals (15.4 %, 95 % CI: 13.2–17.6 %), and environment (17.8 %, 95 % CI: 9.7–27.7 %), respectively. Furthermore, C. jejuni exhibits high resistance rates to antibiotics such as cefoperazone, nalidixic acid, ciprofloxacin, cefradine, and tetracycline. The overall multi-drug resistance rate (MDR) of C. jejuni was 72.8 % (95 % CI: 62.4–82.2 %), indicating a serious problem with MDR. The resistance of C. jejuni to most antibiotics has increased in the last 20 years. Among the main resistance determinants of C. jejuni , gyrA _T86I and tet (O) had a higher pooled prevalence of 94.8 % (95 % CI: 88.7–99.0 %) and 79.0 % (95 % CI: 66.9–89.2 %), respectively. Furthermore, the high prevalence of virulence-related genes was shown in C. jejuni , such as adhesion ( cadF , racR ), invasion ( ciaB , iamA , ceuE ), and toxin ( cdtB, cdtC ). In summary, C. jejuni has a high prevalence with regional characteristics, and antibiotic resistance of this bacterium especially animal sources remains a serious problem in China. Comprehensive monitoring and control measures for this pathogen are urgently needed to ensure food safety and public health. • The prevalence of C. jejuni was highest in the environment, followed by animal, food, and human. • C. jejuni from different sources exhibited high resistance to β-lactams, quinolones, and tetracyclines. • Compared with clinical and food sources, animal-derived strains showed more severe antibiotic resistance. • The high prevalence of quinolone-resistant C. jejuni strains with point mutation gyrA _T86I was observed . • Virulence-related genes (e.g. cadF , ciaB , cdtB , cdtC , cheY ) exhibited high carriage rates.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40027923","pmcid":"PMC11871471","openalex_id":"https://openalex.org/W4407307918","authors":[],"funders":[{"funder_name":"Shanghai Municipal Agricultural Commission","grant_id":"2023-02-08-00-12-F04610","title":null}],"total_grants":1,"fwci":4.5005,"citation_percentile":0.95454545,"influential_citations":0,"citation_trend":[{"year":2025,"count":11},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.onehlt.2025.100990","host_type":"journal"},{"url":"https://doi.org/10.1016/j.onehlt.2025.100990","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352771425000266?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352771425000266?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40027923","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11871471","host_type":"repository"},{"url":"https://doaj.org/article/6b21838a9c98426fbeaa2d0039685edd","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11871471/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11871471","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11871471?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Salmonella and Campylobacter epidemiology","Viral gastroenteritis research and epidemiology","Veterinary medicine and infectious diseases"],"mesh_terms":[],"keywords":["Meta-analysis","Antibiotic resistance","Campylobacter jejuni","Virulence","Microbiology","Campylobacter","Resistance (ecology)","Biology","China","Medicine","Antibiotics","Bacteria","Geography","Ecology","Internal medicine","Genetics","Gene","Prevalence"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T09:58:59.953743Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}