{"doi":"10.1016/j.omton.2025.201078","title":"Pre-clinical evaluation of a potent and effective Pin1-degrading agent in pancreatic cancer","abstract":", causing its degradation in cells. Here, we advanced those agents by improving their plasma stability. We further characterized their mode of action on cancer cells and cancer-associated fibroblasts and studied their efficacy in a syngeneic mouse model of pancreatic cancer peritoneal metastases. Our studies support the hypothesis that these novel Pin1 degraders could be translated into effective therapeutics against peritoneal metastases in pancreatic and other types of gastrointestinal and abdominal cancers that develop peritoneal metastases.","journal":"Molecular Therapy Oncology","year":2025,"id":579693,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":677033,"name":"Tiane Li","orcid":"0009-0002-8022-0080","position":1,"is_corresponding":false},{"id":1490626,"name":"A.M. PRENTISS","orcid":null,"position":2,"is_corresponding":false},{"id":386510,"name":"Parima Udompholkul","orcid":null,"position":3,"is_corresponding":false},{"id":1490225,"name":"Fan Xia","orcid":"0000-0001-8185-8663","position":4,"is_corresponding":false},{"id":392954,"name":"Timothy W. Synold","orcid":"0000-0002-4075-2544","position":5,"is_corresponding":false},{"id":71438,"name":"Jun Wu","orcid":"0000-0002-3381-2561","position":6,"is_corresponding":false},{"id":634407,"name":"Mingye Feng","orcid":"0000-0002-3334-9917","position":7,"is_corresponding":false},{"id":420349,"name":"Mustafa Raoof","orcid":"0000-0003-4710-2226","position":8,"is_corresponding":false},{"id":369395,"name":"Maurizio Pellecchia","orcid":"0000-0001-5179-470X","position":9,"is_corresponding":false},{"id":1244003,"name":"Giulia Alboreggia","orcid":null,"position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:34.718602Z","pmid":"41322199","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}