{"doi":"10.1016/j.omton.2025.201063","title":"Installation of dominant-negative mutations in FAS and TGFβR2 via base editing in primary T cells","abstract":"survival and proliferation assays demonstrate that BE T cells are resistant to pro-apoptotic and anti-proliferative effects of FAS and TGF-β signaling. Chimeric antigen receptor (CAR)-T cells with BE-installed dn TGFβR2 or dn FAS exhibit improvements in cytotoxicity, while dn TGFβR2 CAR T demonstrate increased persistence and reduced expression of phenotypic markers of exhaustion compared to controls. Moreover, BE-engineered dn CAR T outperform lentiviral-engineered cDNA over expression counterparts in several functional assays. Considering the efficiency of BE and its amenability for multiplex editing, our approach lends itself to engineering strategies necessary to overcome T cell dysfunction in solid tumors.","journal":"Molecular Therapy Oncology","year":2025,"id":575743,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":633216,"name":"Mitchell G. Kluesner","orcid":"0000-0001-5828-9204","position":1,"is_corresponding":false},{"id":417672,"name":"Nicholas J. Slipek","orcid":"0000-0003-2664-6507","position":2,"is_corresponding":false},{"id":273414,"name":"Joseph G. Skeate","orcid":"0000-0002-1765-5949","position":3,"is_corresponding":false},{"id":1456226,"name":"Ethan M. Niemeyer","orcid":null,"position":4,"is_corresponding":false},{"id":254328,"name":"Beau R. Webber","orcid":"0000-0002-3950-8747","position":5,"is_corresponding":false},{"id":254329,"name":"Branden S. Moriarity","orcid":"0000-0002-3031-3767","position":6,"is_corresponding":false},{"id":1215854,"name":"Bryce Wick","orcid":"0000-0002-2844-0898","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:57:52.712371Z","pmid":"41141367","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}