{"doi":"10.1016/j.omton.2024.200877","title":"Bridging the antigen-presentation gap for adoptive cell therapies","abstract":"Adoptive cell therapy using polyclonal, antigen-specific T cells has revolutionized the treatment of infections, particularly against adenovirus, Epstein-Barr virus, and cytomegalovirus (CMV) post-hematopoietic stem cell transplantation.1 This therapy has led to remarkable outcomes, including the elimination of high-risk viruses and the cure of refractory virus-associated malignancies. However, recent efforts to expand the applicability of adoptive cell therapy to other diseases have stalled. While generating chimeric antigen receptor T (CAR-T) cells and virus-specific T cells (VSTs) has become more efficient, creating antigen-specific T cell products for low-frequency antigens or multiple antigens remains challenging.","journal":"Molecular Therapy Oncology","year":2024,"id":503819,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263320,"name":"Carolina Colli Cruz","orcid":"0000-0001-7065-3769","position":1,"is_corresponding":false},{"id":750983,"name":"Amy B Hont","orcid":"0000-0002-3663-3956","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T02:10:35.597333Z","pmid":"39391882","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}