{"doi":"10.1016/j.omton.2024.200863","title":"Deletion of the RGD motif from the penton base in oncolytic adenoviruses enhances antitumor efficacy of combined CAR T cell therapy","abstract":"T cells. In addition, ISC301 elicits a heightened pro-inflammatory response in peripheral blood. Importantly, when combined with CAR T cell therapy, ISC301 exhibited superior antitumor efficacy, surpassing monotherapy outcomes. These findings emphasize the impact of adenoviral modifications on antitumor immune responses. The deletion of penton base RGD motifs enhances ISC301's pro-inflammatory profile and boosts CAR T cell therapy efficacy. This study enhances understanding of oncolytic virus engineering strategies, positioning ISC301 as a promising candidate for combined immunotherapeutic approaches in cancer treatment.","journal":"Molecular Therapy Oncology","year":2024,"id":462205,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1291646,"name":"Miguel Ángel Rodríguez-Milla","orcid":"0000-0002-2640-5888","position":1,"is_corresponding":false},{"id":1291647,"name":"Patricia Garcia-Rodriguez","orcid":"0000-0001-9926-4505","position":2,"is_corresponding":false},{"id":787400,"name":"Laura Hidalgo","orcid":null,"position":3,"is_corresponding":false},{"id":91883,"name":"Ramón Alemany","orcid":"0000-0001-8660-550X","position":4,"is_corresponding":false},{"id":1291648,"name":"Javier Garcı́a-Castro","orcid":"0000-0001-7604-1640","position":5,"is_corresponding":false},{"id":1291645,"name":"Álvaro Morales‐Molina","orcid":"0000-0003-4532-7667","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T02:04:20.631898Z","pmid":"39290319","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}