{"doi":"10.1016/j.omton.2024.200862","title":"TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models","abstract":"Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP1, a melanoma differentiation antigen expressed on the surface of melanomas, including rare acral and uveal melanomas. TYRP1-targeted CAR T cells demonstrate antigen-specific activation and cytotoxic activity in vitro and in vivo against human melanomas independent of the MHC alleles and expression. In addition, the toxicity to pigmented normal tissues observed with T lymphocytes expressing TYRP1-targeted TCRs was not observed with TYRP1-targeted CAR T cells. Anti-TYRP1 CAR T cells provide a novel means to target advanced melanomas, serving as a platform for the development of similar novel therapeutic agents and as a tool to interrogate the immunobiology of melanomas.","journal":"Molecular Therapy Oncology","year":2024,"id":441011,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":865537,"name":"Daniel Hirschhorn","orcid":"0000-0003-0467-7687","position":1,"is_corresponding":false},{"id":1253999,"name":"Meixian S Tang","orcid":null,"position":2,"is_corresponding":false},{"id":1253441,"name":"Terence J. Purdon","orcid":"0009-0009-7824-7760","position":3,"is_corresponding":false},{"id":1253442,"name":"Yacine Marouf","orcid":"0000-0002-4621-1407","position":4,"is_corresponding":false},{"id":218305,"name":"Alessandra Piersigilli","orcid":"0000-0001-8943-4996","position":5,"is_corresponding":false},{"id":250489,"name":"Narasimhan P. Agaram","orcid":"0000-0002-6991-2310","position":6,"is_corresponding":false},{"id":229695,"name":"Cailian Liu","orcid":null,"position":7,"is_corresponding":false},{"id":865535,"name":"Sara Schad","orcid":"0000-0002-2306-6999","position":8,"is_corresponding":false},{"id":225995,"name":"Elisa de Stanchina","orcid":"0000-0002-3873-315X","position":9,"is_corresponding":false},{"id":254269,"name":"Sarwish Rafiq","orcid":"0000-0002-9295-3065","position":10,"is_corresponding":false},{"id":467193,"name":"Sébastien Monette","orcid":"0000-0003-2841-6887","position":11,"is_corresponding":false},{"id":3666,"name":"Jedd D. Wolchok","orcid":"0000-0001-6718-2222","position":12,"is_corresponding":false},{"id":109855,"name":"Taha Merghoub","orcid":"0000-0002-1518-5111","position":13,"is_corresponding":false},{"id":243186,"name":"Renier J. Brentjens","orcid":"0000-0002-3364-5388","position":14,"is_corresponding":false},{"id":900635,"name":"Christopher S. Hackett","orcid":"0000-0003-4692-2433","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:01:06.281460Z","pmid":"39308793","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}