{"doi":"10.1016/j.omtn.2023.05.021","title":"Deficiency of miR-409-3p improves myocardial neovascularization and function through modulation of DNAJB9/p38 MAPK signaling","abstract":"Angiogenesis is critical for tissue repair following myocardial infarction (MI), which is exacerbated under insulin resistance or diabetes. MicroRNAs are regulators of angiogenesis. We examined the metabolic regulation of miR-409-3p in post-infarct angiogenesis. miR-409-3p was increased in patients with acute coronary syndrome (ACS) and in a mouse model of acute MI. In endothelial cells (ECs), miR-409-3p was induced by palmitate, while vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) decreased its expression. Overexpression of miR-409-3p decreased EC proliferation and migration in the presence of palmitate, whereas inhibition had the opposite effects. RNA sequencing (RNA-seq) profiling in ECs identified DNAJ homolog subfamily B member 9 (DNAJB9) as a target of miR-409-3p. Overexpression of miR-409-3p decreased DNAJB9 mRNA and protein expression by 47% and 31% respectively, while enriching DNAJB9 mRNA by 1.9-fold after Argonaute2 microribonucleoprotein immunoprecipitation. These effects were mediated through p38 mitogen-activated protein kinase (MAPK). Ischemia-reperfusion (I/R) injury in EC-specific miR-409-3p knockout (KO) mice (miR-409 ECKO ) fed a high-fat, high-sucrose diet increased isolectin B4 (53.3%), CD31 (56%), and DNAJB9 (41.5%). The left ventricular ejection fraction (EF) was improved by 28%, and the infarct area was decreased by 33.8% in miR-409 ECKO compared with control mice. These findings support an important role of miR-409-3p in the angiogenic EC response to myocardial ischemia.","journal":"Molecular Therapy — Nucleic Acids","year":2023,"id":341101,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":347550,"name":"Colette Fritsche","orcid":"0000-0001-9534-8293","position":1,"is_corresponding":false},{"id":1077160,"name":"Kartik Lakhotiya","orcid":null,"position":2,"is_corresponding":false},{"id":1077161,"name":"Carolyn E. Niosi","orcid":null,"position":3,"is_corresponding":false},{"id":1076611,"name":"G. Ghanem","orcid":"0009-0005-1229-1946","position":4,"is_corresponding":false},{"id":446222,"name":"Gregory Martin","orcid":null,"position":5,"is_corresponding":false},{"id":812891,"name":"Ruma Pal‐Ghosh","orcid":null,"position":6,"is_corresponding":false},{"id":305055,"name":"Dakota Becker-Greene","orcid":"0000-0003-0344-8591","position":7,"is_corresponding":false},{"id":1076612,"name":"James A. Weston","orcid":"0000-0001-8269-981X","position":8,"is_corresponding":false},{"id":703461,"name":"Ivana Hollan","orcid":"0000-0001-6939-7534","position":9,"is_corresponding":false},{"id":1077162,"name":"Ivar Risnes","orcid":null,"position":10,"is_corresponding":false},{"id":1077163,"name":"S. E. Rynning","orcid":null,"position":11,"is_corresponding":false},{"id":1077164,"name":"Liv Heidi Solheim","orcid":null,"position":12,"is_corresponding":false},{"id":251597,"name":"Mark W. Feinberg","orcid":"0000-0001-9523-3859","position":13,"is_corresponding":false},{"id":445054,"name":"Robert M. Blanton","orcid":"0000-0002-6837-2076","position":14,"is_corresponding":false},{"id":311907,"name":"Basak Icli","orcid":"0000-0002-4867-8326","position":15,"is_corresponding":false},{"id":1076610,"name":"Furkan Bestepe","orcid":"0000-0002-0451-8224","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:11:03.393978Z","pmid":"37332476","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}