{"doi":"10.1016/j.omtn.2022.08.006","title":"Lung transcriptome of nonhuman primates exposed to total- and partial-body irradiation","abstract":"The focus of radiation biodosimetry has changed recently, and a paradigm shift for using molecular technologies of omic platforms in addition to cytogenetic techniques has been observed. In our study, we have used a nonhuman primate model to investigate the impact of a supralethal dose of 12 Gy radiation on alterations in the lung transcriptome. We used 6 healthy and 32 irradiated animal samples to delineate radiation-induced changes. We also used a medical countermeasure, γ-tocotrienol (GT3), to observe any changes. We demonstrate significant radiation-induced changes in the lung transcriptome for total-body irradiation (TBI) and partial-body irradiation (PBI). However, no major influence of GT3 on radiation was noted in either comparison. Several common signaling pathways, including PI3K/AKT, GADD45, and p53, were upregulated in both exposures. TBI activated DNA-damage-related pathways in the lungs, whereas PTEN signaling was activated after PBI. Our study highlights the various transcriptional profiles associated with γ- and X-ray exposures, and the associated pathways include LXR/RXR activation in TBI, whereas pulmonary wound-healing and pulmonary fibrosis signaling was repressed in PBI. Our study provides important insights into the molecular pathways associated with irradiation that can be further investigated for biomarker discovery.","journal":"Molecular Therapy — Nucleic Acids","year":2022,"id":247842,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9217,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":886113,"name":"Sahil Sethi","orcid":"0009-0001-3891-9798","position":1,"is_corresponding":false},{"id":259918,"name":"Sanjit Pandey","orcid":"0000-0001-7304-3376","position":2,"is_corresponding":false},{"id":703127,"name":"Jatinder Singh","orcid":"0000-0001-5359-9713","position":3,"is_corresponding":false},{"id":490992,"name":"Stephen Y. Wise","orcid":"0000-0002-7613-7455","position":4,"is_corresponding":false},{"id":886114,"name":"Alana D. Carpenter","orcid":"0000-0002-2108-2274","position":5,"is_corresponding":false},{"id":490991,"name":"Oluseyi O. Fatanmi","orcid":"0000-0002-7942-2497","position":6,"is_corresponding":false},{"id":66211,"name":"Chittibabu Guda","orcid":"0000-0002-5393-9316","position":7,"is_corresponding":false},{"id":490993,"name":"Vijay K. Singh","orcid":"0000-0002-6631-3849","position":8,"is_corresponding":false},{"id":320559,"name":"Neetha Nanoth Vellichirammal","orcid":"0000-0002-5740-7093","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-19T00:23:57.824223Z","pmid":"36090752","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}