{"doi":"10.1016/j.omtn.2020.12.015","title":"Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b","abstract":"The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure. Although peroxisome proliferator-activated receptor gamma (PPARγ) activation can suppress RAS, the exact role of PPARγ in AngII-induced muscle atrophy is unclear. Here we identified PPARγ as a negative regulator of miR-29b, a microRNA that is able to promote multiple types of muscle atrophy. Suppression of miR-29b could prevent AngII-induced muscle atrophy both in vitro and in vivo. IGF1, PI3K(p85α), and Yin Yang 1 (YY1) were identified as target genes of miR-29b, and overexpression of these targets could rescue AngII-induced muscle atrophy. Importantly, inhibition of PPARγ was sufficient to induce muscle atrophy, while PPARγ overexpression could attenuate that. These data indicate that the PPARγ/miR-29b axis mediates AngII-induced muscle atrophy, and increasing PPARγ or inhibiting miR-29b represents a promising approach to counteract AngII-induced muscle atrophy. The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure. Although peroxisome proliferator-activated receptor gamma (PPARγ) activation can suppress RAS, the exact role of PPARγ in AngII-induced muscle atrophy is unclear. Here we identified PPARγ as a negative regulator of miR-29b, a microRNA that is able to promote multiple types of muscle atrophy. Suppression of miR-29b could prevent AngII-induced muscle atrophy both in vitro and in vivo. IGF1, PI3K(p85α), and Yin Yang 1 (YY1) were identified as target genes of miR-29b, and overexpression of these targets could rescue AngII-induced muscle atrophy. Importantly, inhibition of PPARγ was sufficient to induce muscle atrophy, while PPARγ overexpression could attenuate that. These data indicate that the PPARγ/miR-29b axis mediates AngII-induced muscle atrophy, and increasing PPARγ or inhibiting miR-29b represents a promising approach to counteract AngII-induced muscle atrophy.","journal":"Molecular Therapy — Nucleic Acids","year":2020,"id":96876,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350197,"name":"Tingting Yang","orcid":"0000-0002-5220-588X","position":1,"is_corresponding":false},{"id":480234,"name":"Zhao Sha","orcid":null,"position":2,"is_corresponding":false},{"id":352035,"name":"Haifei Tang","orcid":null,"position":3,"is_corresponding":false},{"id":352034,"name":"Xuejiao Hua","orcid":null,"position":4,"is_corresponding":false},{"id":350196,"name":"Lijun Wang","orcid":"0000-0002-3686-6098","position":5,"is_corresponding":false},{"id":480235,"name":"Zitong Wang","orcid":null,"position":6,"is_corresponding":false},{"id":479597,"name":"Ziyu Gao","orcid":"0000-0003-2808-0826","position":7,"is_corresponding":false},{"id":241161,"name":"Joost P. G. Sluijter","orcid":"0000-0003-2088-9102","position":8,"is_corresponding":false},{"id":356406,"name":"Glenn C. Rowe","orcid":"0000-0002-8195-9605","position":9,"is_corresponding":false},{"id":251878,"name":"Saumya Das","orcid":"0000-0002-4521-4606","position":10,"is_corresponding":false},{"id":14249,"name":"Liming Yang","orcid":"0000-0002-0390-8845","position":11,"is_corresponding":false},{"id":251877,"name":"Junjie Xiao","orcid":"0000-0002-9202-0003","position":12,"is_corresponding":false},{"id":479596,"name":"Li Jin","orcid":"0000-0002-7168-4679","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"33614226","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}