{"doi":"10.1016/j.omtm.2025.101646","title":"HBVZ10, an AAV8 vector-based new HBV therapy candidate for cccDNA elimination","abstract":"cccDNA replenishment, we developed HBVZ10, a gene therapy candidate that utilizes an optimized adeno-associated virus (AAV) vector 8 to deliver human anti-HBs antibody genes into muscle cells for expanding endogenous anti-HBs antibody production capacity. HBVZ10 expression and therapeutic function were evaluated in uPA/SCID chimeric mice. HBVZ10 therapy achieved sustained antibody expression of ≥100,000 mIU/mL for at least 200 days following a single dose administration. Combining HBVZ10 with intracellular replication inhibitor entecavir resulted in >100-fold reductions in cccDNA within a few months, accompanied by progressive reductions in serum HBeAg and HBsAg to undetectable levels. These findings establish preclinical evidence of HBVZ10 as a novel gene therapy candidate and support a paradigm-shifting cccDNA elimination strategy.","journal":"Molecular Therapy — Methods & Clinical Development","year":2025,"id":581885,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1170855,"name":"Yuanping Zhou","orcid":"0000-0002-2493-396X","position":1,"is_corresponding":false},{"id":304996,"name":"Stephen Horrigan","orcid":"0000-0003-3055-7101","position":2,"is_corresponding":false},{"id":679131,"name":"Laura Luckenbaugh","orcid":null,"position":3,"is_corresponding":false},{"id":593399,"name":"Jianming Hu","orcid":"0000-0002-4418-605X","position":4,"is_corresponding":false},{"id":1023082,"name":"Fabien Zoulim","orcid":"0000-0002-2245-0083","position":5,"is_corresponding":false},{"id":1170857,"name":"Yongyuan Zhang","orcid":"0000-0001-9337-1553","position":6,"is_corresponding":false},{"id":1493415,"name":"Bai-Hua Zhang","orcid":"0009-0002-1850-0233","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:51.328454Z","pmid":"41404410","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}