{"doi":"10.1016/j.omtm.2023.101124","title":"The hunt for novel AAV capsids with improved cardiac tropism","abstract":"The last two decades have shown an impressive progress in the development of viral vectors, leading to the approval for commercialization by the FDA of seven gene therapies based on adeno-associated viral vectors (AAVs). This was made possible due to improvements already attained in vector structure to mitigate immunogenicity, prevent off-target expression, increase transgene expression, and reduce neutralizing antibody recognition.1,2 However, some research areas are still lagging behind, as is the case for gene therapy targeting cardiac diseases.","journal":"Molecular Therapy — Methods & Clinical Development","year":2023,"id":377829,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.945,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317255,"name":"Eugenio Cingolani","orcid":"0000-0001-5939-8111","position":1,"is_corresponding":false},{"id":948473,"name":"Rodrigo Miguel‐dos‐Santos","orcid":"0000-0001-8839-3416","position":0,"is_corresponding":true}],"reference_count":6,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37886605","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}