{"doi":"10.1016/j.omtm.2022.12.005","title":"Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo","abstract":". The results demonstrated that the Alx647 probe did not alter the fundamental properties of P188 to protect biological membranes. Distribution kinetics in mdx mice demonstrated that Alx647 did not interface with muscle membranes and had fast clearance kinetics. In contrast, the distribution kinetics for P188-Alx647 was significantly slower, indicating a dramatic depot and retention effect of P188. Results further demonstrated the significant retention of P188-Alx647 in the skeletal muscle of mdx mice, showing a significant genotype effect with a higher fluorescence signal in the mdx muscles over BL10 mice. High-resolution optical imaging provided direct evidence of P188 surrounding the sarcolemma of skeletal and cardiac muscle cells. Taken together, these findings provide direct evidence of muscle-disease-dependent molecular homing and retention of synthetic copolymers in striated muscles thereby facilitating advanced studies of copolymer-membrane association in health and disease.","journal":"Molecular Therapy — Methods & Clinical Development","year":2022,"id":278318,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296236,"name":"Houda Cohen","orcid":"0000-0003-4375-8797","position":1,"is_corresponding":false},{"id":950434,"name":"Mihee Kim","orcid":"0000-0002-6258-7287","position":2,"is_corresponding":false},{"id":764166,"name":"Dongwoo Hahn","orcid":"0000-0001-6850-932X","position":3,"is_corresponding":false},{"id":950855,"name":"Nicholas Van Zee","orcid":null,"position":4,"is_corresponding":false},{"id":408884,"name":"Timothy P. Lodge","orcid":"0000-0001-5916-8834","position":5,"is_corresponding":false},{"id":499401,"name":"Marc A. Hillmyer","orcid":"0000-0001-8255-3853","position":6,"is_corresponding":false},{"id":408882,"name":"Benjamin J. Hackel","orcid":"0000-0003-3561-9463","position":7,"is_corresponding":false},{"id":408883,"name":"Frank S. Bates","orcid":"0000-0003-3977-1278","position":8,"is_corresponding":false},{"id":296239,"name":"Joseph M. Metzger","orcid":"0000-0002-3882-4326","position":9,"is_corresponding":false},{"id":296238,"name":"Addeli Bez Batti Angulski","orcid":"0000-0002-4636-5457","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:28:43.133347Z","pmid":"36654800","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}