{"doi":"10.1016/j.omtm.2021.11.007","title":"Promoter considerations in the design of lentiviral vectors for use in treating lysosomal storage diseases","abstract":"lentiviral-mediated gene therapy needs optimization in dose, time of delivery, and promoter-driven expression. Choosing suitable promoters seems to be one of the important factors for the effective expression of the dysfunctional enzyme. This review summarizes the research on therapy for LSDs that has used different lentiviral vectors, emphasizing gene promoters.","journal":"Molecular Therapy — Methods & Clinical Development","year":2021,"id":172990,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":710756,"name":"Takashi Higuchi","orcid":null,"position":1,"is_corresponding":false},{"id":709987,"name":"Hiroshi Kobayashi","orcid":"0000-0002-0924-1252","position":2,"is_corresponding":false},{"id":709988,"name":"Deni S. Galileo","orcid":"0000-0002-0089-2198","position":3,"is_corresponding":false},{"id":709989,"name":"Grzegorz Węgrzyn","orcid":"0000-0003-4042-7466","position":4,"is_corresponding":false},{"id":267050,"name":"Shunji Tomatsu","orcid":"0000-0002-0673-2160","position":5,"is_corresponding":false},{"id":709986,"name":"Estera Rintz","orcid":"0000-0003-4941-766X","position":0,"is_corresponding":true}],"reference_count":139,"raw_metadata":null,"created_at":"2026-07-18T23:46:45.768135Z","pmid":"34977274","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}