{"doi":"10.1016/j.omtm.2020.03.022","title":"Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo","abstract":"and how the targeting enhances bioactivity of the IL-27 cytokine. We applied the IL-27 gene delivery protocol utilizing sonoporation (sonodelivery) with the goal of reducing prostate tumor growth in an immunocompetent TC2R C57/BL6 model. The reduction in tumor growth and effector cellular profiles implicate targeted IL-27 as more effective than an untargeted version of IL-27 in promoting bioactivity, as assessed by STAT1 and IFN-γ reporter genes. Moreover, enhanced antitumor effects and significantly higher accumulation of natural killer T (NKT) and CD8 effector cells in the tumors were observed. These results support a novel IL-27-based targeting strategy that is promising since it shows improved therapeutic efficacy while utilizing simple and effective sonodelivery methods.","journal":"Molecular Therapy — Methods & Clinical Development","year":2020,"id":75943,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":396719,"name":"Manoel Figueiredo Neto","orcid":null,"position":1,"is_corresponding":false},{"id":395996,"name":"Janelle W. Salameh","orcid":"0000-0001-8458-9956","position":2,"is_corresponding":false},{"id":395997,"name":"R DECKER","orcid":"0000-0002-6620-8045","position":3,"is_corresponding":false},{"id":395998,"name":"Rachel A. Letteri","orcid":"0000-0002-2919-203X","position":4,"is_corresponding":false},{"id":395999,"name":"Delphine Chan‐Seng","orcid":"0000-0003-3508-2491","position":5,"is_corresponding":false},{"id":396000,"name":"Todd Emrick","orcid":"0000-0003-0460-1797","position":6,"is_corresponding":false},{"id":395995,"name":"Marxa L. Figueiredo","orcid":"0000-0002-8134-0749","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:46:55.856612Z","pmid":"32346551","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}